Technology Process of Benzoic acid, 4-(aminomethyl)-3-methyl-, methyl ester
There total 3 articles about Benzoic acid, 4-(aminomethyl)-3-methyl-, methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 4-cyano-3-methylbenzoate;
With
cobalt(II) chloride;
In
methanol;
at 0 - 20 ℃;
for 0.25h;
With
sodium tetrahydroborate;
In
methanol;
at 20 ℃;
for 1.5h;
With
ammonia;
In
methanol; water;
at 20 ℃;
for 0.5h;
- Guidance literature:
-
carbon monoxide; 4-bromo-2-methylbenzonitrile;
With
triethylamine;
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate;
In
methanol; acetonitrile;
at 100 ℃;
for 24h;
under 6465.65 Torr;
With
ammonia; hydrogen; nickel;
In
methanol;
at 40 ℃;
for 18h;
under 3142.81 Torr;
- Guidance literature:
-
3,4-dimethylbenzoic acid;
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile);
In
chloroform;
at 80 ℃;
for 4h;
Inert atmosphere;
methanol;
With
thionyl chloride;
at 0 - 70 ℃;
for 2h;
Overall yield = 0.57g; Further stages;
Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b00398
