Benzenesulfonamide, 4-amino-N-methyl-N-2-pyridinyl-

Base Information

• Chemical Name: Benzenesulfonamide, 4-amino-N-methyl-N-2-pyridinyl-
• CAS No.: 51543-29-4
• Molecular Formula: C12H13N3O2S
• Molecular Weight: 263.32
• ChEMBL ID: CHEMBL407684
• DSSTox Substance ID: DTXSID50478452
• Nikkaji Number: J1.567.500D
• Wikidata: Q82311844
• Mol file: 51543-29-4.mol

Synonyms:51543-29-4;Benzenesulfonamide, 4-amino-N-methyl-N-2-pyridinyl-;CHEMBL407684;DTXSID50478452;AKOS000205771

Chemical Property of Benzenesulfonamide, 4-amino-N-methyl-N-2-pyridinyl-

Chemical Property:

• Refractive Index: 1.6740 (estimate)
• PSA: 84.67000
• Density: 1.2864 (rough estimate)
• LogP: 3.15090
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 263.07284784
• Heavy Atom Count: 18
• Complexity: 358

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C1=CC=CC=N1)S(=O)(=O)C2=CC=C(C=C2)N

Technology Process of Benzenesulfonamide, 4-amino-N-methyl-N-2-pyridinyl-

There total 8 articles about Benzenesulfonamide, 4-amino-N-methyl-N-2-pyridinyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H11N3O4S → 4-amino-N-methyl-N-pyridin-2-yl-benzenesulfonamide (51543-29-4)

Guidance literature:

With iron; ammonium chloride; In methanol; water; at 70 ℃; for 4h;

DOI:10.1021/jm401334s

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + sulphapyridine (144-83-2) → 4-amino-N-(1-methyl-1H-pyridin-2-ylidene)-benzenesulfonamide (58944-05-1) + 4-amino-N-methyl-N-pyridin-2-yl-benzenesulfonamide (51543-29-4)

Guidance literature:

With diethyl ether;

DOI:10.1021/ja01263a002

Reference yield:

4-Nitrobenzenesulfonyl chloride (98-74-8) → 4-amino-N-methyl-N-pyridin-2-yl-benzenesulfonamide (51543-29-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 0 - 20 °C

2: iron; ammonium chloride / methanol; water / 4 h / 70 °C

With iron; ammonium chloride; In methanol; dichloromethane; water;

DOI:10.1021/jm401334s

upstream raw materials:

diazomethane

sulphapyridine

N-acetylsulfapyridine

diethyl ether