1,4-DIIODO-2,3-DIMETHOXYBENZENE

Base Information

• Chemical Name: 1,4-DIIODO-2,3-DIMETHOXYBENZENE
• CAS No.: 51560-25-9
• Molecular Formula: C8H8I2O2
• Molecular Weight: 389.959
• Hs Code.: 2909309090
• Mol file: 51560-25-9.mol

Synonyms:Benzene,1,4-diiodo-2,3-dimethoxy;

Chemical Property of 1,4-DIIODO-2,3-DIMETHOXYBENZENE

Chemical Property:

• Boiling Point: 360.9±42.0 °C(Predicted)
• PSA: 18.46000
• Density: 2.147±0.06 g/cm3(Predicted)
• LogP: 2.91300

Purity/Quality:

97% or 98% ^*data from raw suppliers

1,4-Diiodo-2,3-dimethoxybenzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-DIIODO-2,3-DIMETHOXYBENZENE

There total 4 articles about 1,4-DIIODO-2,3-DIMETHOXYBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1,4-bis(trimethylsilyl)-2,3-dimethoxybenzene (92669-92-6) → 1,4-diiodo-2,3-dimethoxybenzene (51560-25-9)

Guidance literature:

With Iodine monochloride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/ejoc.200900751

Reference yield:

1,2-dimethoxybenzene (91-16-7) → 1,4-diiodo-2,3-dimethoxybenzene (51560-25-9)

Guidance literature:

Multistep reaction; (i) nBuLi, Me₂NCH₂CH₂NMe₂, heptane, hexane, (ii) I₂;

Reference yield:

1-trimethylsilyl-2,3-dimethoxybenzene (92669-91-5) → 1,4-diiodo-2,3-dimethoxybenzene (51560-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi; TMEDA / hexane / 25 h / 20 °C

1.2: 89 percent / hexane / 5 h / -78 - 20 °C

2.1: 80.9 percent / ICl / CH₂Cl₂ / 0.5 h / 20 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; Iodine monochloride; In hexane; dichloromethane;

DOI:10.1021/ol0164886

upstream raw materials:

1,2-dimethoxybenzene

1,4-bis(trimethylsilyl)-2,3-dimethoxybenzene

1-trimethylsilyl-2,3-dimethoxybenzene

Downstream raw materials:

C₁₄H₁₉IO₅

C₁₄H₁₈BrIO₅

C₂₄H₃₄INO₉

C₅₁H₅₈N₈O₉

Refernces

• 1、 -. "SPIRO COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS". . . Retrieved 2015/11/09.
• 2、 Liu, Lei,Wang, Xiaojun,Zhang, Quan,Li, Qiaowei,Zhao, Yanli. "Distinct interpenetrated metal-organic frameworks constructed from crown ether-based strut analogue". . p. 841 - 844. Retrieved 2013/03/13.