2-[(6-CHLORO-3-PYRIDAZINYL)AMINO]-1-ETHANOL

Base Information

• Chemical Name: 2-[(6-CHLORO-3-PYRIDAZINYL)AMINO]-1-ETHANOL
• CAS No.: 51947-89-8
• Molecular Formula: C6H8ClN3O
• Molecular Weight: 173.60000
• Hs Code.: 2933990090
• Mol file: 51947-89-8.mol

Synonyms:2-[(6-chloro-3-pyridazinyl)amino]ethanol;Ethanol,2-[(6-chloro-3-pyridazinyl)amino];

Chemical Property of 2-[(6-CHLORO-3-PYRIDAZINYL)AMINO]-1-ETHANOL

Chemical Property:

• Vapor Pressure: 2.25E-09mmHg at 25°C
• Melting Point: 133-135 °C
• Boiling Point: 463.1oC at 760 mmHg
• PKA: 14.49±0.10(Predicted)
• Flash Point: 233.9oC
• PSA: 58.04000
• Density: 1.431g/cm3
• LogP: 0.60720

Purity/Quality:

98%min ^*data from raw suppliers

2-[(6-chloro-3-pyridazinyl)amino]-1-ethanol ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 36/37

MSDS Files:

Useful:

Technology Process of 2-[(6-CHLORO-3-PYRIDAZINYL)AMINO]-1-ETHANOL

There total 2 articles about 2-[(6-CHLORO-3-PYRIDAZINYL)AMINO]-1-ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,6-dichlorpyridazine (141-30-0) + ethanolamine (141-43-5) → 3-(2-Hydroxy-ethylamino)-6-chlor-pyridazin (51947-89-8)

Guidance literature:

In ethanol; Heating;

DOI:10.1016/S0040-4039(03)00426-X

Reference yield:

→ 3-(2-Hydroxy-ethylamino)-6-chlor-pyridazin (51947-89-8)

Guidance literature:

3,6-Dichlor-pyridazin, Ethanolamin, Δ/A.;

Reference yield: 82.0%

3-(2-Hydroxy-ethylamino)-6-chlor-pyridazin (51947-89-8) → 6-chloroimidazo[1,2-b]pyridazine (6775-78-6)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃;

DOI:10.1016/S0040-4039(03)00426-X

upstream raw materials:

3,6-dichlorpyridazine

ethanolamine

Downstream raw materials:

6-chloroimidazo[1,2-b]pyridazine

Refernces

• 1、 Raboisson, Pierre,Mekonnen, Belew,Peet, Norton P.. "Efficient preparation of imidazo[1,2-b]pyridazines under Swern oxidative conditions". . p. 2919 - 2921. Retrieved 2007/10/03.