2-Oxazolidinone, 3-[[2,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxy-3-methylphen yl]acetyl]-4-(phenylmethyl)-, (4R)-

Base Information

Chemical Name:2-Oxazolidinone, 3-[[2,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxy-3-methylphen yl]acetyl]-4-(phenylmethyl)-, (4R)-
CAS No.:526217-87-8
Molecular Formula:C32H49NO6Si2
Molecular Weight:599.915
Hs Code.:

Synonyms:

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Chemical Property of 2-Oxazolidinone, 3-[[2,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxy-3-methylphen yl]acetyl]-4-(phenylmethyl)-, (4R)-

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Technology Process of 2-Oxazolidinone, 3-[[2,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxy-3-methylphen yl]acetyl]-4-(phenylmethyl)-, (4R)-

There total 11 articles about 2-Oxazolidinone, 3-[[2,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxy-3-methylphen yl]acetyl]-4-(phenylmethyl)-, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: C₂₇H₄₈O₆Si₂

: 526217-87-8
4-benzyl-3-{[2,5-bis-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-3-methyl-phenyl]-acetyl}-oxazolidin-2-one

Guidance literature:: (R)-4-(phenylmethyl)-2-oxazolidinone; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

C₂₇H₄₈O₆Si₂; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1021/ja034397t

Reference yield:

: 2207-57-0
2-methoxy-3-methyl-1,4-benzoquinone

: 526217-87-8
4-benzyl-3-{[2,5-bis-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-3-methyl-phenyl]-acetyl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: imidazole / dimethylformamide / 20 h / 20 °C

2.1: NBS / acetonitrile / 6 h / 20 °C

3.1: 71 percent / PdCl₂[P(o-tolyl)3]2; zinc bromide / dimethylformamide / 24 h / 80 °C

4.1: DIBAL-H / CH₂Cl₂ / 6 h / -78 - 0 °C

5.1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

6.1: aq. NaClO₂; KH₂PO₄; Me₂C=CMe₂ / 2-methyl-propan-2-ol / 12 h / 20 °C

7.1: Et₃N / CH₂Cl₂ / 1.5 h / -78 - 0 °C

8.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

8.2: 352 mg / tetrahydrofuran; hexane / -78 - 20 °C

With 1H-imidazole; sodium chlorite; potassium dihydrogenphosphate; N-Bromosuccinimide; n-butyllithium; 2,3-Dimethyl-2-butene; oxalyl dichloride; dichlorobis(tri-O-tolylphosphine)palladium; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; zinc dibromide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 3.1: Negishi-Reformatsky coupling / 5.1: Swern oxidation / 6.1: Pinnick oxidation;
DOI:10.1021/ja034397t

Reference yield:

: 7149-92-0
2,4-dimethoxy-3-methylbenzaldehyde

: 526217-87-8
4-benzyl-3-{[2,5-bis-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-3-methyl-phenyl]-acetyl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: MCPBA / CH₂Cl₂ / 5 h / 20 °C

2.1: aq. NaOH / methanol / 4 h / 20 °C

3.1: aq. CAN / acetonitrile / 1 h / 20 °C

4.1: imidazole / dimethylformamide / 20 h / 20 °C

5.1: NBS / acetonitrile / 6 h / 20 °C

6.1: 71 percent / PdCl₂[P(o-tolyl)3]2; zinc bromide / dimethylformamide / 24 h / 80 °C

7.1: DIBAL-H / CH₂Cl₂ / 6 h / -78 - 0 °C

8.1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

9.1: aq. NaClO₂; KH₂PO₄; Me₂C=CMe₂ / 2-methyl-propan-2-ol / 12 h / 20 °C

10.1: Et₃N / CH₂Cl₂ / 1.5 h / -78 - 0 °C

11.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

11.2: 352 mg / tetrahydrofuran; hexane / -78 - 20 °C

With 1H-imidazole; sodium hydroxide; sodium chlorite; potassium dihydrogenphosphate; N-Bromosuccinimide; n-butyllithium; 2,3-Dimethyl-2-butene; oxalyl dichloride; dichlorobis(tri-O-tolylphosphine)palladium; ammonium cerium(IV) nitrate; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; zinc dibromide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 6.1: Negishi-Reformatsky coupling / 8.1: Swern oxidation / 9.1: Pinnick oxidation;
DOI:10.1021/ja034397t