4-[(2-phenylacetyl)amino]butanoic acid

Base Information

• Chemical Name: 4-[(2-phenylacetyl)amino]butanoic acid
• CAS No.: 2937-01-1
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.256
• Mol file: 2937-01-1.mol

Synonyms:4-(2-phenyl-acetylamino)-butyric acid;4-(2-phenylacetamido)butanoic acid;4-Phenylacetylamino-butyric acid;4-(2-Phenyl-acetylamino)-buttersaeure;4-<2-Phenylacetamino>-buttersaeure;N-phenylacetyl-4-aminobutyric acid;HMS2752H16;

Chemical Property of 4-[(2-phenylacetyl)amino]butanoic acid

Chemical Property:

• Vapor Pressure: 8.96E-11mmHg at 25°C
• Boiling Point: 498.9°Cat760mmHg
• Flash Point: 255.5°C
• PSA: 66.40000
• Density: 1.171g/cm³
• LogP: 1.60100

Purity/Quality:

99%min ^*data from raw suppliers

4-[(2-Phenylacetyl)amino]butanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[(2-phenylacetyl)amino]butanoic acid

There total 2 articles about 4-[(2-phenylacetyl)amino]butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

phenylacetyl chloride (103-80-0) + 4-amino-n-butyric acid (56-12-2) → 4-[(phenylacetyl)amino]butanoic acid (2937-01-1)

Guidance literature:

With sodium carbonate; sodium hydroxide; In diethyl ether; at 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2014.06.057

Reference yield:

→ 4-[(phenylacetyl)amino]butanoic acid (2937-01-1)

Guidance literature:

4-Amino-buttersaeure, wss. NaOH + Na2CO3, Phenylacetylchlorid, Ae.;

Reference yield: 46.0%

4-[(phenylacetyl)amino]butanoic acid (2937-01-1) + 8-amino-3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl[1]benzothieno[3,2-d]pyrimidin-4(3H)-one (1621318-17-9) + chloroformic acid ethyl ester (541-41-3) → N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[(phenylacetyl)amino]butanamide (1621318-28-2)

Guidance literature:

4-[(phenylacetyl)amino]butanoic acid; With triethylamine; In tetrahydrofuran; for 0.0833333h; Cooling with ice;

chloroformic acid ethyl ester; In tetrahydrofuran; at 0 - 5 ℃; for 3h;

8-amino-3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl[1]benzothieno[3,2-d]pyrimidin-4(3H)-one; In tetrahydrofuran; at 20 ℃; for 120h;

DOI:10.1016/j.ejmech.2014.06.057

upstream raw materials:

phenylacetyl chloride

4-amino-n-butyric acid

Downstream raw materials:

N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[(phenylacetyl)amino]butanamide

Refernces

• 1、 Romeo, Giuseppe,Salerno, Loredana,Pittalà, Valeria,Modica, Maria N.,Siracusa, Maria A.,Materia, Luisa,Buccioni, Michela,Marucci, Gabriella,Minneman, Kenneth P.. "High affinity ligands and potent antagonists for the α1D- adrenergic receptor. Novel 3,8-disubstituted [1]benzothieno[3,2-d]pyrimidine derivatives". . p. 419 - 432. Retrieved 2014/07/21.
• 2、 -. "Composition containing a penem or carbapenem antibiotic". . . Retrieved 2008/06/13.