N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[(phenylacetyl)amino]butanamide

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Chemical Name:N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[(phenylacetyl)amino]butanamide
CAS No.:1621318-28-2
Molecular Formula:C₃₆H₄₀N₆O₄S
Molecular Weight:652.817
Hs Code.:

Synonyms:N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[(phenylacetyl)amino]butanamide

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Chemical Property of N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[(phenylacetyl)amino]butanamide

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Technology Process of N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[(phenylacetyl)amino]butanamide

There total 3 articles about N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[(phenylacetyl)amino]butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 2937-01-1
4-[(phenylacetyl)amino]butanoic acid

: 1621318-17-9
8-amino-3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl[1]benzothieno[3,2-d]pyrimidin-4(3H)-one

: 541-41-3
chloroformic acid ethyl ester

: 1621318-28-2
N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[(phenylacetyl)amino]butanamide

Guidance literature:: 4-[(phenylacetyl)amino]butanoic acid; With triethylamine; In tetrahydrofuran; for 0.0833333h; Cooling with ice;

chloroformic acid ethyl ester; In tetrahydrofuran; at 0 - 5 ℃; for 3h;

8-amino-3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl[1]benzothieno[3,2-d]pyrimidin-4(3H)-one; In tetrahydrofuran; at 20 ℃; for 120h;
DOI:10.1016/j.ejmech.2014.06.057

Reference yield:

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 1621318-28-2
N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[(phenylacetyl)amino]butanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 160 °C

2.1: hydrazine hydrate / N,N-dimethyl-formamide / 120 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 0.08 h / Cooling with ice

3.2: 3 h / 0 - 5 °C

3.3: 120 h / 20 °C

With hydrazine hydrate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.06.057

Reference yield:

: 103-80-0
phenylacetyl chloride

: 1621318-28-2
N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[(phenylacetyl)amino]butanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate; sodium hydroxide / diethyl ether / 3 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 0.08 h / Cooling with ice

2.2: 3 h / 0 - 5 °C

2.3: 120 h / 20 °C

With sodium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; diethyl ether;
DOI:10.1016/j.ejmech.2014.06.057