Propanethioic acid, 2,2-dimethyl-, S-(phenylmethyl) ester

Base Information

• Chemical Name: Propanethioic acid, 2,2-dimethyl-, S-(phenylmethyl) ester
• CAS No.: 53573-34-5
• Molecular Formula: C12H16OS
• Molecular Weight: 208.324
• Mol file: 53573-34-5.mol

Synonyms:

Chemical Property of Propanethioic acid, 2,2-dimethyl-, S-(phenylmethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanethioic acid, 2,2-dimethyl-, S-(phenylmethyl) ester

There total 7 articles about Propanethioic acid, 2,2-dimethyl-, S-(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,2-dimethylpropanoic anhydride (1538-75-6) + phenylmethanethiol (100-53-8) → 2,2-dimethylthiopropionic acid S-benzyl ester (53573-34-5)

Guidance literature:

With potassium carbonate; In ethyl acetate; at 20 ℃; for 8h; chemoselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.07.126

Reference yield: 92.0%

phenylmethanethiol (100-53-8) + Trimethylacetic acid (75-98-9) → 2,2-dimethylthiopropionic acid S-benzyl ester (53573-34-5)

Guidance literature:

With PPE; for 15h; Ambient temperature;

DOI:10.1055/s-1982-29716

Reference yield: 33.0%

3-(benzylthio)-1,2-benzisothiazole 1,1-dioxide (75908-55-3) + pivaloyl chloride (3282-30-2) → 2,2-dimethylthiopropionic acid S-benzyl ester (53573-34-5)

Guidance literature:

With piperidine; triethylamine; In acetonitrile; for 1.5h; Ambient temperature;

DOI:10.1246/bcsj.56.949

upstream raw materials:

phenylmethanethiol

Trimethylacetic acid

3-(benzylthio)-1,2-benzisothiazole 1,1-dioxide

pivaloyl chloride