5,11-Dioxa-2,14-diazapentadecanedioic acid, 2,14-bis(methoxymethyl)-4,12-dioxo-3,13-bis(phenylmethyl)-, bis(1,1-dimethylethyl) ester, (3S,13S)-

Base Information

Chemical Name:5,11-Dioxa-2,14-diazapentadecanedioic acid, 2,14-bis(methoxymethyl)-4,12-dioxo-3,13-bis(phenylmethyl)-, bis(1,1-dimethylethyl) ester, (3S,13S)-
CAS No.:536730-40-2
Molecular Formula:C37H54N2O10
Molecular Weight:686.843
Hs Code.:

5,11-Dioxa-2,14-diazapentadecanedioic acid,
2,14-bis(methoxymethyl)-4,12-dioxo-3,13-bis(phenylmethyl)-,
bis(1,1-dimethylethyl) ester, (3S,13S)-

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Chemical Property of 5,11-Dioxa-2,14-diazapentadecanedioic acid, 2,14-bis(methoxymethyl)-4,12-dioxo-3,13-bis(phenylmethyl)-, bis(1,1-dimethylethyl) ester, (3S,13S)-

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Technology Process of 5,11-Dioxa-2,14-diazapentadecanedioic acid, 2,14-bis(methoxymethyl)-4,12-dioxo-3,13-bis(phenylmethyl)-, bis(1,1-dimethylethyl) ester, (3S,13S)-

There total 3 articles about 5,11-Dioxa-2,14-diazapentadecanedioic acid, 2,14-bis(methoxymethyl)-4,12-dioxo-3,13-bis(phenylmethyl)-, bis(1,1-dimethylethyl) ester, (3S,13S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 111-29-5
1 ,5-pentanediol

: 432023-52-4
(S)-N-tert-butoxycarbonyl-N-(methoxymethyl)phenylalanine

: 536730-40-2
(2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenylpropionic acid 5-[(2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenyl-propionyloxy]-pentyl ester

Guidance literature:: With 4-dimethylpyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 - 20 ℃; for 15h;
DOI:10.1016/S0040-4020(02)01626-5

Reference yield:

: 66617-58-1
N-(tert-butoxycarbonyl)-L-phenylalanine benzyl ester

: 536730-40-2
(2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenylpropionic acid 5-[(2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenyl-propionyloxy]-pentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: KHMDS / tetrahydrofuran / 0.17 h / -78 °C

1.2: 79 percent / tetrahydrofuran / 21 h / -78 °C

2.1: 92 percent / H₂ / 10 percent Pd/C / ethyl acetate / 15 h

3.1: 64 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide; 4-dimethylpyridine / CH₂Cl₂ / 15 h / 0 - 20 °C

With 4-dimethylpyridine; hydrogen; potassium hexamethylsilazane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(02)01626-5

Reference yield:

: 536730-54-8
(S)-N-tert-butoxycarbonyl-N-(methoxymethyl)phenylalanine benzyl ester

: 536730-40-2
(2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenylpropionic acid 5-[(2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenyl-propionyloxy]-pentyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / H₂ / 10 percent Pd/C / ethyl acetate / 15 h

2: 64 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide; 4-dimethylpyridine / CH₂Cl₂ / 15 h / 0 - 20 °C

With 4-dimethylpyridine; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(02)01626-5