alpha-(p-Chlorobenzyl)-2-thenylamine hydrochloride

Base Information

• Chemical Name: alpha-(p-Chlorobenzyl)-2-thenylamine hydrochloride
• CAS No.: 80154-70-7
• Molecular Formula: C₁₂H₁₂ClNS*ClH
• Molecular Weight: 274.214
• DSSTox Substance ID: DTXSID201001013

Synonyms:alpha-(p-Chlorobenzyl)-2-thenylamine hydrochloride;2-Thenylamine, alpha-(p-chlorobenzyl)-, hydrochloride;80154-70-7;DTXSID201001013;LS-149327;2-(4-Chlorophenyl)-1-(thiophen-2-yl)ethan-1-amine--hydrogen chloride (1/1)

Chemical Property of alpha-(p-Chlorobenzyl)-2-thenylamine hydrochloride

Chemical Property:

• Vapor Pressure: 9.54E-05mmHg at 25°C
• Boiling Point: 338.9°C at 760 mmHg
• Flash Point: 158.7°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 273.0145760
• Heavy Atom Count: 16
• Complexity: 192

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CSC(=C1)C(CC2=CC=C(C=C2)Cl)N.Cl

Technology Process of alpha-(p-Chlorobenzyl)-2-thenylamine hydrochloride

There total 2 articles about alpha-(p-Chlorobenzyl)-2-thenylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-(4-chlorophenyl)-2-(2-thienyl)-2-ethanone (67947-51-7) → 1-(2-thienyl)-2-(4-chlorophenyl)ethylamine hydrochloride (80154-70-7)

Guidance literature:

With formic acid; ammonium carbonate;

Reference yield:

4-chlorophenacetyl chloride (25026-34-0) → 1-(2-thienyl)-2-(4-chlorophenyl)ethylamine hydrochloride (80154-70-7)

Guidance literature:

Multi-step reaction with 2 steps

2: 62 percent / (NH₄)2CO₃, HCOOH

With formic acid; ammonium carbonate;

Reference yield: 39.0%

ethyl iodide (75-03-6) + 1-(2-thienyl)-2-(4-chlorophenyl)ethylamine hydrochloride (80154-70-7) → [2-(4-Chloro-phenyl)-1-thiophen-2-yl-ethyl]-diethyl-amine; hydrochloride (80154-72-9)

Guidance literature:

With silver(l) oxide; 1.) reflux, 1 h, 2.) 20 deg C, 1 h;

upstream raw materials:

1-(4-chlorophenyl)-2-(2-thienyl)-2-ethanone

4-chlorophenacetyl chloride

Downstream raw materials:

[2-(4-Chloro-phenyl)-1-thiophen-2-yl-ethyl]-diethyl-amine; hydrochloride

[2-(4-Chloro-phenyl)-1-thiophen-2-yl-ethyl]-isopropyl-amine; hydrochloride

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