Diethyl [phenyl(trimethylsilyl)methyl]propanedioate

Base Information

• Chemical Name: Diethyl [phenyl(trimethylsilyl)methyl]propanedioate
• CAS No.: 54056-54-1
• Molecular Formula: C17H26O4Si
• Molecular Weight: 322.477
• DSSTox Substance ID: DTXSID20573721
• Nikkaji Number: J1.689.375G
• Mol file: 54056-54-1.mol

Synonyms:54056-54-1;Diethyl [phenyl(trimethylsilyl)methyl]propanedioate;DTXSID20573721

Chemical Property of Diethyl [phenyl(trimethylsilyl)methyl]propanedioate

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 322.16003584
• Heavy Atom Count: 22
• Complexity: 351

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(C(C1=CC=CC=C1)[Si](C)(C)C)C(=O)OCC

Technology Process of Diethyl [phenyl(trimethylsilyl)methyl]propanedioate

There total 2 articles about Diethyl [phenyl(trimethylsilyl)methyl]propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

chloro-trimethyl-silane (75-77-4) + diethyl benzalmalonate (5292-53-5) → 2-(Phenyl-trimethylsilanyl-methyl)-malonic acid diethyl ester (54056-54-1)

Guidance literature:

With tetrabutylammomium bromide; In N,N-dimethyl-formamide; electroreduction at reactive Mg anode;

DOI:10.1016/S0040-4039(00)61132-2

Reference yield: 70.0%

chloro-trimethyl-silane (75-77-4) + diethyl benzalmalonate (5292-53-5) → 2-(Phenyl-trimethylsilanyl-methyl)-malonic acid diethyl ester (54056-54-1) + diethyl 2-benzylmalonate (607-81-8)

Guidance literature:

With magnesium; In N,N-dimethyl-formamide; at 15 - 20 ℃; for 9h;

DOI:10.1246/cl.2002.228

upstream raw materials:

chloro-trimethyl-silane

diethyl benzalmalonate