Phthalimide, N-(1-formylethyl)-

Base Information

• Chemical Name: Phthalimide, N-(1-formylethyl)-
• CAS No.: 23101-87-3
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.197
• DSSTox Substance ID: DTXSID00945780
• Nikkaji Number: J2.586.096I
• Mol file: 23101-87-3.mol

Synonyms:23101-87-3;Phthalimide, N-(1-formylethyl)-;2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanal;2-(1,3-dioxoisoindol-2-yl)propanal;Phthalimide, N-(1-formylethyl)-,;2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal;2-phthalimidopropanal;2-phthalimidopropanaldehyde;SCHEMBL4715603;DTXSID00945780;FT-0690342;EN300-719616;Z1509728847;2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal #

Chemical Property of Phthalimide, N-(1-formylethyl)-

Chemical Property:

• Vapor Pressure: 0.0002mmHg at 25°C
• Boiling Point: 327.6°Cat760mmHg
• Flash Point: 148°C
• Density: 1.336g/cm³
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 203.058243149
• Heavy Atom Count: 15
• Complexity: 289

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C=O)N1C(=O)C2=CC=CC=C2C1=O

Technology Process of Phthalimide, N-(1-formylethyl)-

There total 31 articles about Phthalimide, N-(1-formylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-((2S)-1-hydroxypropan-2-yl)-1H-isoindole-1,3(2H)-dione (70058-19-4) → 2-(N-phthaloylamino)propanal (51482-36-1,23101-87-3)

Guidance literature:

With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.5h; pH=6;

DOI:10.1016/j.tetasy.2003.12.011

Reference yield: 85.0%

(S)-2-phthalimidopropionyl chloride (4306-25-6) → 2-(N-phthaloylamino)propanal (51482-36-1,23101-87-3)

Guidance literature:

With hydrogen; Pd-BaSO₄; In xylene; at 110 ℃; for 10h;

DOI:10.1016/0957-4166(92)80017-Q

Reference yield: 70.0%

(2R,3R)-2-phthalimidobutane-1,2-diol (105763-33-5) → (R)-(+)-2-N-phthalimidopropanal (73365-03-4,23101-87-3)

Guidance literature:

With lead(IV) acetate; In benzene; at 22 ℃; for 0.5h;

DOI:10.1021/jo00376a046

upstream raw materials:

(S)-2-phthalimidopropionyl chloride

N-vinylphthalimide

carbon monoxide

N-(3,3-diethoxypropyl)phthalimide

Downstream raw materials:

(R)-N-phthaloylalanine

Phth-L-Ala-OH

(R)-4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-methyl-pentanethioic acid S-phenyl ester

(2R,3S,4S)-4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-methyl-pentanethioic acid S-phenyl ester