Technology Process of 2-Propenoic acid, [(1E)-1,3-butadienylcyclohexylmethylsilyl]methyl ester
There total 5 articles about 2-Propenoic acid, [(1E)-1,3-butadienylcyclohexylmethylsilyl]methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 0.333333h;
DOI:10.1016/S0040-4020(03)00261-8
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 41 percent / CuCN / diethyl ether / Heating
2.1: Mg; ZnCl2; dibromoethane / tetrahydrofuran / 4.5 h / Heating
2.2: CuCN / tetrahydrofuran / 0 °C
2.3: 38 percent / I2 / benzene / 3.5 h / Heating
3.1: n-Bu4NBr; TiO2 / 3 h / 80 - 90 °C
4.1: LiAlH4 / diethyl ether / 0.5 h / -20 - 20 °C
5.1: 40 percent / DEAD; PPh3 / tetrahydrofuran / 0.33 h / -78 - 20 °C
With
lithium aluminium tetrahydride; 1,1-Dibromoethane; tetrabutylammomium bromide; titanium(IV) oxide; magnesium; triphenylphosphine; zinc(II) chloride; diethylazodicarboxylate;
In
tetrahydrofuran; diethyl ether;
1.1: Grignard reaction / 2.2: Grignard reaction / 5.1: Mitsunobu reaction;
DOI:10.1016/S0040-4020(03)00261-8
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Mg; ZnCl2; dibromoethane / tetrahydrofuran / 4.5 h / Heating
1.2: CuCN / tetrahydrofuran / 0 °C
1.3: 38 percent / I2 / benzene / 3.5 h / Heating
2.1: n-Bu4NBr; TiO2 / 3 h / 80 - 90 °C
3.1: LiAlH4 / diethyl ether / 0.5 h / -20 - 20 °C
4.1: 40 percent / DEAD; PPh3 / tetrahydrofuran / 0.33 h / -78 - 20 °C
With
lithium aluminium tetrahydride; 1,1-Dibromoethane; tetrabutylammomium bromide; titanium(IV) oxide; magnesium; triphenylphosphine; zinc(II) chloride; diethylazodicarboxylate;
In
tetrahydrofuran; diethyl ether;
1.2: Grignard reaction / 4.1: Mitsunobu reaction;
DOI:10.1016/S0040-4020(03)00261-8