4-propylbicyclo[2.2.2]octane-1-carboxylic acid

Base Information

• Chemical Name: 4-propylbicyclo[2.2.2]octane-1-carboxylic acid
• CAS No.: 5605-11-8
• Molecular Formula: C12H20O2
• Molecular Weight: 196.29
• Hs Code.: 2916209090
• Mol file: 5605-11-8.mol

Synonyms:4-n-propylbicyclo(2.2.2)octane-1-carboxylic acid;4-propylbicyclo(2.2.2)octanecarboxylic acid;4-Propylbicyclo[2.2.2]octan-1-carbonsaeure;

Chemical Property of 4-propylbicyclo[2.2.2]octane-1-carboxylic acid

Chemical Property:

• PSA: 37.30000
• LogP: 3.21170

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-propylbicyclo[2.2.2]octane-1-carboxylic acid

There total 3 articles about 4-propylbicyclo[2.2.2]octane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

formic acid (64-18-6) + 1-n-Propyl-4-brombicyclo<2.2.2>octan (76921-50-1) → 4-propylbicyclo<2.2.2>octane-1-carboxylic acid (5605-11-8)

Guidance literature:

With sulfuric acid; silver sulfate; at 0 ℃; for 6h;

DOI:10.1080/00268948108073606

Reference yield:

2-oxo-6-propyl-2H-pyran-3-carboxylic acid ethyl ester (100059-41-4) + ethene (74-85-1) → 4-propylbicyclo<2.2.2>octane-1-carboxylic acid (5605-11-8)

Guidance literature:

Multistep reaction; (i), (ii) H₂, Pd-C, EtOH;

DOI:10.1021/jm00296a021

Reference yield:

→ 4-propylbicyclo<2.2.2>octane-1-carboxylic acid (5605-11-8)

Guidance literature:

Ester (I, R = 2-CH3), H2 / Pd-C sowie mit NaOH;

upstream raw materials:

2-oxo-6-propyl-2H-pyran-3-carboxylic acid ethyl ester

ethene

formic acid

1-n-Propyl-4-brombicyclo<2.2.2>octan

Downstream raw materials:

4-propylbicyclo(2.2.2)octane-1-carboxylic acid chloride

4-propylbicyclo(2.2.2)octylacetylene