N-(1-CYANOCYCLOHEXYL)ACETAMIDE

Base Information

• Chemical Name: N-(1-CYANOCYCLOHEXYL)ACETAMIDE
• CAS No.: 4550-68-9
• Molecular Formula: C9H14 N2 O
• Molecular Weight: 166.223
• Hs Code.: 2926909090
• Mol file: 4550-68-9.mol

Synonyms:N-(1-cyanocyclohexyl)ethanamide

Chemical Property of N-(1-CYANOCYCLOHEXYL)ACETAMIDE

Chemical Property:

• Vapor Pressure: 3.53E-06mmHg at 25°C
• Boiling Point: 386.5°Cat760mmHg
• Flash Point: 187.5°C
• PSA: 52.89000
• Density: 1.05g/cm³
• LogP: 1.73988

Purity/Quality:

97% ^*data from raw suppliers

N-(1-Cyanocyclohexyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-CYANOCYCLOHEXYL)ACETAMIDE

There total 5 articles about N-(1-CYANOCYCLOHEXYL)ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

acetyl chloride (75-36-5) + 1-amino-1-cyanocyclohexane (5496-10-6) → 1-acetamidocyclohexanecarbonitrile (4550-68-9)

Guidance literature:

With trimethylamine; In diethyl ether; at 20 ℃; Cooling with ice;

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-acetamidocyclohexanecarbonitrile (4550-68-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NH₃ / methanol / 1 h / 0 °C

1.2: 93 percent / Nh₄Cl; aq. NH₃ / methanol / 18 h / 20 °C

2.1: Et₃N / diethyl ether / 3 h / 20 °C

With ammonia; triethylamine; In methanol; diethyl ether;

DOI:10.1081/SCC-120021988

Reference yield:

acetic anhydride (108-24-7) + 1-amino-1-cyanocyclohexane (5496-10-6) → 1-acetamidocyclohexanecarbonitrile (4550-68-9)

Guidance literature:

upstream raw materials:

acetic anhydride

1-amino-1-cyanocyclohexane

potassium cyanide

cyclohexanone

Downstream raw materials:

1-acetylamino-1-(acetylamino-methyl)-cyclohexane

N-acetyl-3,4,5,6-tetrahydroaniline

1-(N-acetylamino)cyclohexylcarboxylic acid

1-acetamidocyclohexanecarboxamide