Technology Process of Octanoic acid,
8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,5-dihydroxy-2,4-dimethyl-,
2,6-dimethylphenyl ester, (2R,3R,4S,5R)-
There total 9 articles about Octanoic acid,
8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,5-dihydroxy-2,4-dimethyl-,
2,6-dimethylphenyl ester, (2R,3R,4S,5R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
at 20 ℃;
for 3h;
atmospheric pressure;
DOI:10.1021/jm0204136
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 95 percent / lithium borohydride / methanol; tetrahydrofuran / 2.33 h / 0 - 20 °C
2.1: 72 percent / pyridinium p-toluenesulfonate / benzene / 15 h / Heating
3.1: diisobutylaluminum hydride / tetrahydrofuran; CH2Cl2 / 1 h / 0 °C
4.1: pyridinium sulfur trioxide; diisopropylethylamine / dimethylsulfoxide; CH2Cl2 / 1 h / 20 °C
5.1: LDA / tetrahydrofuran / 1 h / -78 °C
5.2: 73 percent / tetrahydrofuran / 2 h / -78 - 20 °C
6.1: H2 / Pd/C / ethyl acetate / 3 h / 20 °C / atmospheric pressure
With
lithium borohydride; hydrogen; sulfur trioxide pyridine complex; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; benzene;
1.1: Evans syn-aldol condensation / 6.2: Heathcock's aldol reaction;
DOI:10.1021/jm0204136
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 95 percent / pyridinium sulfur trioxide
2.1: 95 percent / lithium borohydride / methanol; tetrahydrofuran / 2.33 h / 0 - 20 °C
3.1: 72 percent / pyridinium p-toluenesulfonate / benzene / 15 h / Heating
4.1: diisobutylaluminum hydride / tetrahydrofuran; CH2Cl2 / 1 h / 0 °C
5.1: pyridinium sulfur trioxide; diisopropylethylamine / dimethylsulfoxide; CH2Cl2 / 1 h / 20 °C
6.1: LDA / tetrahydrofuran / 1 h / -78 °C
6.2: 73 percent / tetrahydrofuran / 2 h / -78 - 20 °C
7.1: H2 / Pd/C / ethyl acetate / 3 h / 20 °C / atmospheric pressure
With
lithium borohydride; hydrogen; sulfur trioxide pyridine complex; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; benzene;
3.1: Evans syn-aldol condensation / 8.2: Heathcock's aldol reaction;
DOI:10.1021/jm0204136
