Octanoic acid, 8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-5-[(4-methoxyphenyl) methoxy]-2,4-dimethyl-, 2,6-dimethylphenyl ester, (2R,3R,4R,5R)-

Base Information

Chemical Name:Octanoic acid, 8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-5-[(4-methoxyphenyl) methoxy]-2,4-dimethyl-, 2,6-dimethylphenyl ester, (2R,3R,4R,5R)-
CAS No.:479673-24-0
Molecular Formula:C32H50O6Si
Molecular Weight:558.831
Hs Code.:

Octanoic acid,
8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-5-[(4-methoxyphenyl)
methoxy]-2,4-dimethyl-, 2,6-dimethylphenyl ester, (2R,3R,4R,5R)-

Synonyms:

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Chemical Property of Octanoic acid, 8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-5-[(4-methoxyphenyl) methoxy]-2,4-dimethyl-, 2,6-dimethylphenyl ester, (2R,3R,4R,5R)-

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Technology Process of Octanoic acid, 8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-5-[(4-methoxyphenyl) methoxy]-2,4-dimethyl-, 2,6-dimethylphenyl ester, (2R,3R,4R,5R)-

There total 7 articles about Octanoic acid, 8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-5-[(4-methoxyphenyl) methoxy]-2,4-dimethyl-, 2,6-dimethylphenyl ester, (2R,3R,4R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87184-99-4
4-tert-butyldimethylsilyloxybutan-1-ol

: 479673-24-0
(2R,3R,4R,5R)-8-(tert-butyldimethylsilanyloxy)-3-hydroxy-5-(4-methoxybenzyloxy)-2,4-dimethyloctanoic acid, 2,6-dimethylphenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 95 percent / pyridinium sulfur trioxide

2.1: 95 percent / lithium borohydride / methanol; tetrahydrofuran / 2.33 h / 0 - 20 °C

3.1: 72 percent / pyridinium p-toluenesulfonate / benzene / 15 h / Heating

4.1: diisobutylaluminum hydride / tetrahydrofuran; CH₂Cl₂ / 1 h / 0 °C

5.1: pyridinium sulfur trioxide; diisopropylethylamine / dimethylsulfoxide; CH₂Cl₂ / 1 h / 20 °C

6.1: LDA / tetrahydrofuran / 1 h / -78 °C

6.2: 73 percent / tetrahydrofuran / 2 h / -78 - 20 °C

With lithium borohydride; sulfur trioxide pyridine complex; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; benzene; 2.1: Evans syn-aldol condensation / 7.2: Heathcock's aldol reaction;
DOI:10.1021/jm0204136

Reference yield:

: 154919-93-4
(S)-4-Benzyl-3-[(2S,3R)-6-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2-methyl-hexanoyl]-oxazolidin-2-one

: 479673-24-0
(2R,3R,4R,5R)-8-(tert-butyldimethylsilanyloxy)-3-hydroxy-5-(4-methoxybenzyloxy)-2,4-dimethyloctanoic acid, 2,6-dimethylphenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / lithium borohydride / methanol; tetrahydrofuran / 2.33 h / 0 - 20 °C

2.1: 72 percent / pyridinium p-toluenesulfonate / benzene / 15 h / Heating

3.1: diisobutylaluminum hydride / tetrahydrofuran; CH₂Cl₂ / 1 h / 0 °C

4.1: pyridinium sulfur trioxide; diisopropylethylamine / dimethylsulfoxide; CH₂Cl₂ / 1 h / 20 °C

5.1: LDA / tetrahydrofuran / 1 h / -78 °C

5.2: 73 percent / tetrahydrofuran / 2 h / -78 - 20 °C

With lithium borohydride; sulfur trioxide pyridine complex; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; benzene; 5.2: Heathcock's aldol reaction;
DOI:10.1021/jm0204136

Reference yield:

: 87184-81-4
4-(tert-butyldimethylsilanyloxy)butanal

: 479673-24-0
(2R,3R,4R,5R)-8-(tert-butyldimethylsilanyloxy)-3-hydroxy-5-(4-methoxybenzyloxy)-2,4-dimethyloctanoic acid, 2,6-dimethylphenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / lithium borohydride / methanol; tetrahydrofuran / 2.33 h / 0 - 20 °C

2.1: 72 percent / pyridinium p-toluenesulfonate / benzene / 15 h / Heating

3.1: diisobutylaluminum hydride / tetrahydrofuran; CH₂Cl₂ / 1 h / 0 °C

4.1: pyridinium sulfur trioxide; diisopropylethylamine / dimethylsulfoxide; CH₂Cl₂ / 1 h / 20 °C

5.1: LDA / tetrahydrofuran / 1 h / -78 °C

5.2: 73 percent / tetrahydrofuran / 2 h / -78 - 20 °C

With lithium borohydride; sulfur trioxide pyridine complex; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; benzene; 1.1: Evans syn-aldol condensation / 6.2: Heathcock's aldol reaction;
DOI:10.1021/jm0204136