Technology Process of 4-Morpholinecarboxylic acid,
2,3-dimethoxy-2,3,5-trimethyl-6-oxo-5-(phenylmethyl)-, phenylmethyl
ester, (2S,3R,5S)-
There total 6 articles about 4-Morpholinecarboxylic acid,
2,3-dimethoxy-2,3,5-trimethyl-6-oxo-5-(phenylmethyl)-, phenylmethyl
ester, (2S,3R,5S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -55 ℃;
for 21h;
DOI:10.1016/j.tet.2004.06.063
- Guidance literature:
-
benzyl (2S,3R,5R)-5-benzyl-2,3-dimethoxy-2,3-dimethyl-6-oxomorpholine-4-carboxylate;
With
lithium diisopropyl amide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
at -78 ℃;
for 1h;
methyl iodide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
at -55 ℃;
for 21h;
Further stages.;
DOI:10.1039/b210673f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 69 percent / BF3*THF / CH2Cl2 / 2.5 h / 30 °C
2.1: 64 percent / KHMDS / tetrahydrofuran; toluene / 24 h / -78 - 20 °C
3.1: 85 percent / aq. NaIO4; acetonitrile / RuCl3 / CCl4 / 20 °C
4.1: lithium diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / -78 °C
4.2: tetrahydrofuran; hexamethylphosphoric acid triamide / 21 h / -55 °C
5.1: lithium diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / -78 °C
5.2: 66 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 21 h / -55 °C
With
sodium periodate; boron trifluoride-tetrahydrofuran complex; potassium hexamethylsilazane; acetonitrile; lithium diisopropyl amide;
ruthenium trichloride;
In
tetrahydrofuran; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; toluene;
3.1: Sharpless reaction;
DOI:10.1039/b210673f
