H-LEU-GLY-OTBU HCL

Base Information

• Chemical Name: H-LEU-GLY-OTBU HCL
• CAS No.: 56610-13-0
• Molecular Formula: C12H24N2O3
• Molecular Weight: 244.334
• Mol file: 56610-13-0.mol

Synonyms:L-leucyl-glycine tert-butyl ester;((S)-2-Amino-4-methyl-pentanoylamino)-acetic acid tert-butyl ester;

Chemical Property of H-LEU-GLY-OTBU HCL

Chemical Property:

• PSA: 81.42000
• LogP: 1.90890
• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

H-LEU-GLY-OTBU HCL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-LEU-GLY-OTBU HCL

There total 6 articles about H-LEU-GLY-OTBU HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

[(S)-4-Methyl-2-((3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxycarbonylamino)-pentanoylamino]-acetic acid tert-butyl ester → D-Glucose (2280-44-6) + L-Leu-Gly-O-t-Bu (56610-13-0)

Guidance literature:

With phosphate buffer; β-glucosidase; α-glucosidase; In methanol; at 37 ℃; pH 5.5;

DOI:10.1016/S0008-6215(97)00224-3

Reference yield:

tert-butyl (N-benzyloxycarbonyl-(S)-leucyl)glycinate (6401-56-5) → L-Leu-Gly-O-t-Bu (56610-13-0)

Guidance literature:

With hydrogen; palladium(IV) oxide; In methanol;

DOI:10.1021/ja00460a039

Reference yield:

Z-Leu-OH (2018-66-8) → L-Leu-Gly-O-t-Bu (56610-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran / 20 °C

2: ammonium formate / palladium on charcoal / methanol / 20 °C

With 4-methyl-morpholine; ammonium formate; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1002/chem.200700084

upstream raw materials:

tert-butyl (N-benzyloxycarbonyl-(S)-leucyl)glycinate

Z-Leu-OH

Glycine tert-butyl ester

Z-Leu-ONp

Downstream raw materials:

Z-Leu-Leu-Gly-OBu^t

((S)-4-Methyl-2-{[(S)-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoylamino)-acetic acid tert-butyl ester

Z-Gln-Leu-Leu-Gly-OBu^t

Z-Gln-Gln-Leu-Leu-Gly-OBu^t