((S)-4-Methyl-2-{[(S)-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoylamino)-acetic acid tert-butyl ester

Base Information

• Chemical Name: ((S)-4-Methyl-2-{[(S)-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoylamino)-acetic acid tert-butyl ester
• CAS No.: 104379-72-8
• Molecular Formula: C₂₄H₃₉N₃O₅S
• Molecular Weight: 481.657
• Mol file: 104379-72-8.mol

Synonyms:

Chemical Property of ((S)-4-Methyl-2-{[(S)-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoylamino)-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((S)-4-Methyl-2-{[(S)-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoylamino)-acetic acid tert-butyl ester

There total 4 articles about ((S)-4-Methyl-2-{[(S)-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoylamino)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((2S)-1-p-toluenesulfonyl-2-pyrrolidinyl)methanol (55456-48-9) → ((S)-4-Methyl-2-{[(S)-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoylamino)-acetic acid tert-butyl ester (104379-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / oxalyl chloride, DMF / dimethylsulfoxide

2: 1.) 5A molecular sieves, 2.) bromcresol, NaCNBH₃, HCl gas / 1.) THF, overnight, 2.) EtOH, 25 deg C, 2 d

With hydrogenchloride; oxalyl dichloride; 5A molecular sieve; 2-bromo-6-methylphenol; sodium cyanoborohydride; N,N-dimethyl-formamide; In dimethyl sulfoxide;

DOI:10.1021/jm00156a012

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → ((S)-4-Methyl-2-{[(S)-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoylamino)-acetic acid tert-butyl ester (104379-72-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / H₂O; acetone / 10 °C

2: 96 percent / oxalyl chloride, DMF / dimethylsulfoxide

3: 1.) 5A molecular sieves, 2.) bromcresol, NaCNBH₃, HCl gas / 1.) THF, overnight, 2.) EtOH, 25 deg C, 2 d

With hydrogenchloride; oxalyl dichloride; 5A molecular sieve; 2-bromo-6-methylphenol; sodium cyanoborohydride; N,N-dimethyl-formamide; In water; dimethyl sulfoxide; acetone;

DOI:10.1021/jm00156a012

Reference yield:

(S)-1-Pyrrolidin-2-yl-methanol (23356-96-9) → ((S)-4-Methyl-2-{[(S)-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoylamino)-acetic acid tert-butyl ester (104379-72-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / H₂O; acetone / 10 °C

2: 96 percent / oxalyl chloride, DMF / dimethylsulfoxide

3: 1.) 5A molecular sieves, 2.) bromcresol, NaCNBH₃, HCl gas / 1.) THF, overnight, 2.) EtOH, 25 deg C, 2 d

With hydrogenchloride; oxalyl dichloride; 5A molecular sieve; 2-bromo-6-methylphenol; sodium cyanoborohydride; N,N-dimethyl-formamide; In water; dimethyl sulfoxide; acetone;

DOI:10.1021/jm00156a012

upstream raw materials:

L-Leu-Gly-O-t-Bu

(S)-1-<(4-methylphenyl)sulfonyl>-2-pyrrolidinecarboxaldehyde

((2S)-1-p-toluenesulfonyl-2-pyrrolidinyl)methanol

p-toluenesulfonyl chloride

Downstream raw materials:

(S)-N--2-pyrrolidinyl>methyl>-L-leucyl>glycine