Technology Process of 1,4-Benzenedicarboxylic acid, 2-fluoro-5-(phenylamino)-, dimethyl ester
There total 3 articles about 1,4-Benzenedicarboxylic acid, 2-fluoro-5-(phenylamino)-, dimethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium diacetate; caesium carbonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine);
In
toluene;
at 90 ℃;
for 24h;
DOI:10.1021/jm070299x
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 percent / nitric acid; sulfuric acid / 0.25 h / 0 °C
2: 90 percent / H2 / Pd/C / ethyl acetate / 1 h
3: 80 percent / (S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; cesium carbonate; palladium(II) acetate / toluene / 24 h / 90 °C
With
sulfuric acid; hydrogen; nitric acid; palladium diacetate; caesium carbonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine);
palladium on activated charcoal;
In
ethyl acetate; toluene;
3: Buchwald-Hartwig coupling;
DOI:10.1021/jm070299x
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 90 percent / H2 / Pd/C / ethyl acetate / 1 h
2: 80 percent / (S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; cesium carbonate; palladium(II) acetate / toluene / 24 h / 90 °C
With
hydrogen; palladium diacetate; caesium carbonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine);
palladium on activated charcoal;
In
ethyl acetate; toluene;
2: Buchwald-Hartwig coupling;
DOI:10.1021/jm070299x
