Technology Process of 3-Acridinecarboxamide,
2-fluoro-9,10-dihydro-N-[1-methyl-1-[4-(methylthio)phenyl]ethyl]-9-oxo-
There total 6 articles about 3-Acridinecarboxamide,
2-fluoro-9,10-dihydro-N-[1-methyl-1-[4-(methylthio)phenyl]ethyl]-9-oxo- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 95 percent / nitric acid; sulfuric acid / 0.25 h / 0 °C
2: 90 percent / H2 / Pd/C / ethyl acetate / 1 h
3: 80 percent / (S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; cesium carbonate; palladium(II) acetate / toluene / 24 h / 90 °C
4: 100 percent / lithium hydroxide monohydrate / methanol; tetrahydrofuran; H2O / 0.5 h / 75 °C
5: 84 percent / polyphosphoric acid / 0.17 h / 165 °C
6: triethylamine; N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride / dimethylformamide / 20 °C
With
lithium hydroxide; PPA; N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; sulfuric acid; hydrogen; nitric acid; palladium diacetate; caesium carbonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
3: Buchwald-Hartwig coupling;
DOI:10.1021/jm070299x
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 90 percent / H2 / Pd/C / ethyl acetate / 1 h
2: 80 percent / (S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; cesium carbonate; palladium(II) acetate / toluene / 24 h / 90 °C
3: 100 percent / lithium hydroxide monohydrate / methanol; tetrahydrofuran; H2O / 0.5 h / 75 °C
4: 84 percent / polyphosphoric acid / 0.17 h / 165 °C
5: triethylamine; N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride / dimethylformamide / 20 °C
With
lithium hydroxide; PPA; N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; hydrogen; palladium diacetate; caesium carbonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
2: Buchwald-Hartwig coupling;
DOI:10.1021/jm070299x
- Guidance literature:
-
With
N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
DOI:10.1021/jm070299x
