1-benzhydryl-4-[(Z)-3-phenylprop-2-enyl]piperazine

Base Information

Chemical Name:1-benzhydryl-4-[(Z)-3-phenylprop-2-enyl]piperazine
CAS No.:16699-20-0
Molecular Formula:C₂₆H₂₈N₂
Molecular Weight:368.522
Hs Code.:
ChEMBL ID:CHEMBL1257123
Mol file:16699-20-0.mol

Synonyms:(Z)-Cinnarizine;750512-44-8;1-benzhydryl-4-[(Z)-3-phenylprop-2-enyl]piperazine;EINECS 240-749-2;(Z)-1-(DIPHENYLMETHYL)-4-(3-PHENYLPROP-2-ENYL)PIPERAZINE;Cinnarizine EP Impurity B;NCGC00015246-02;CAS-298-57-7;Piperazine, 1-cinnamyl-4-(diphenylmethyl)-, (E)-;Lopac-C-5270;Piperazine, 1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-, (E)-;CHEMBL1257123;SCHEMBL16225873;1-(Diphenylmethyl)-4-[(2Z)-3-phenyl-2-propen-1-yl]piperazine;AKOS015960696;CS-O-07634;NSC 290687;NCGC00015246-01;NCGC00018187-01;NCGC00018187-02;AC-12048;(Z)-1-Diphenylmethyl-4-(3-phenylprop-2-enyl)piperazine;(z)-1-(diphenylmethyl)-4-(3-phenylprop-2-en-1-yl)piperazine

Suppliers and Price of 1-benzhydryl-4-[(Z)-3-phenylprop-2-enyl]piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of 1-benzhydryl-4-[(Z)-3-phenylprop-2-enyl]piperazine

Chemical Property:

Vapor Pressure:1.74E-10mmHg at 25°C
Boiling Point:509.2°Cat760mmHg
Flash Point:229.8°C
PSA：6.48000
Density:1.093g/cm³
LogP:4.98280
XLogP3:5.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:368.225248902
Heavy Atom Count:28
Complexity:429

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4
Isomeric SMILES:C1CN(CCN1C/C=C\C2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4
Recent EU Clinical Trials:Prospective randomised double blind comparative study of cinnarizine versus placebo as prophylactic anti-travel sickness therapy in patients undergoing dy-case gynaecological surgery.

Technology Process of 1-benzhydryl-4-[(Z)-3-phenylprop-2-enyl]piperazine

There total 36 articles about 1-benzhydryl-4-[(Z)-3-phenylprop-2-enyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 4393-06-0
1-Phenyl-2-propen-1-ol

: 841-77-0
diphenylmethylpiperazine

: 298-57-7,16699-20-0
cinnarizine

Guidance literature:: With Pd(xantphos)(MeCN)₂(OTf)₂; In isopropyl alcohol; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1055/s-0034-1379249

Reference yield: 90.0%

: 104-54-1
3-Phenylpropenol

: 841-77-0
diphenylmethylpiperazine

: 298-57-7,16699-20-0
cinnarizine

Guidance literature:: In o-xylene; at 150 ℃; for 30h; Inert atmosphere; Sealed tube;
DOI:10.1016/j.jcat.2019.12.012

Reference yield: 90.0%

: 1-[(2E)-3-chloroprop-2-en-1-yl]-4-(diphenylmethyl)piperazine

: 100-59-4
phenylmagnesium chloride

: 298-57-7,16699-20-0
cinnarizine

Guidance literature:: With 1-methyl-pyrrolidin-2-one; iron(III)-acetylacetonate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1134/S1070428015010169