4-(METHYLSULFANYL)-2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE

Base Information

• Chemical Name: 4-(METHYLSULFANYL)-2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE
• CAS No.: 57663-06-6
• Molecular Formula: C13H10N2OS
• Molecular Weight: 242.29600
• Mol file: 57663-06-6.mol

Synonyms:4-methylsulfanyl-2-oxo-6-phenyl-1,2-dihydro-pyridine-3-carbonitrile;3-cyano-4-methylthio-6-phenyl-2(1H)-pyridone;3-Cyano-4-methylthio-6-phenyl-2(1H)-pyrridon;3-cyano-6-phenyl-4-methylthio-2H-pyridone;

Chemical Property of 4-(METHYLSULFANYL)-2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE

Chemical Property:

• PSA: 81.95000
• LogP: 2.63548

Purity/Quality:

99% ^*data from raw suppliers

4-(Methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(METHYLSULFANYL)-2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE

There total 5 articles about 4-(METHYLSULFANYL)-2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3,3-bis(methylthio)-1-phenylprop-2-en-1-one (13636-88-9) + cyanoacetic acid amide (107-91-5) → 4-(methylthio)-2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile (57663-06-6)

Guidance literature:

With sodium isopropylate; In isopropyl alcohol; for 2h; Reflux;

DOI:10.1016/j.tet.2010.02.047

Reference yield: 43.0%

6-phenyl-3-cyano-4-methylsulfanyl-2H-pyran-2-one (61380-85-6) → 4-(methylthio)-2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile (57663-06-6) + 4-methylsulfanyl-6-phenyl-pyridin-2-ylamine

Guidance literature:

With urea; at 150 ℃; for 0.25h;

DOI:10.1055/s-2005-862365

Reference yield: 26.0%

2-cyano-3,3-bis(methylthio)acrylamide (17823-69-7) + acetophenone (98-86-2) → 4-(methylthio)-2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile (57663-06-6)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; for 8h; Ambient temperature;

upstream raw materials:

[Bis(methylthio)methylene]malononitrile

acetophenone

2-cyano-3,3-bis(methylthio)acrylamide

6-phenyl-3-cyano-4-methylsulfanyl-2H-pyran-2-one

Downstream raw materials:

2-chloro-3-cyano-6-phenyl-4-methylthiopyridine

3-Amino-4-methylthio-6-phenyl-1H-pyrazolo<3,4-b>pyridin

4-(methylsulfinyl)-2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile

3-amino-6-phenyl-2H-pyrazolo[4,3-c]pyridin-4(5H)-one acetate