Pyrido[2,3-d]pyrimidine-6-carboxylic acid, 1,2,3,4,7,8-hexahydro-1,3-dimethyl-2,4,7-trioxo-, ethyl ester

Base Information

• Chemical Name: Pyrido[2,3-d]pyrimidine-6-carboxylic acid, 1,2,3,4,7,8-hexahydro-1,3-dimethyl-2,4,7-trioxo-, ethyl ester
• CAS No.: 57821-19-9
• Molecular Formula: C₁₂H₁₃N₃O₅
• Molecular Weight: 279.252
• Mol file: 57821-19-9.mol

Synonyms:6-Carbethoxy-1,3-dimethyl-2,4,7-trioxopyrido[2,3-d]pyrimidine;

Chemical Property of Pyrido[2,3-d]pyrimidine-6-carboxylic acid, 1,2,3,4,7,8-hexahydro-1,3-dimethyl-2,4,7-trioxo-, ethyl ester

Chemical Property:

• PSA: 103.16000
• LogP: -0.89780

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrido[2,3-d]pyrimidine-6-carboxylic acid, 1,2,3,4,7,8-hexahydro-1,3-dimethyl-2,4,7-trioxo-, ethyl ester

There total 1 articles about Pyrido[2,3-d]pyrimidine-6-carboxylic acid, 1,2,3,4,7,8-hexahydro-1,3-dimethyl-2,4,7-trioxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

diethyl malonate (105-53-3) + 1,3-dimethyl-5-cyanouracil (36980-91-3) → 1,3-dimethylpyrido<2,3-d>pyrimidine-2,4(1H,3H)-dione (24410-21-7) + 6-Ethoxycarbonyl-1,3-dimethylpyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione (57821-19-9) + 7-amino-6-ethoxycarbonyl-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine (84725-60-0)

Guidance literature:

With sodium ethanolate; In ethanol; for 20h; Product distribution; Mechanism; Heating;

DOI:10.1002/jhet.5570210560

Reference yield:

6-Ethoxycarbonyl-1,3-dimethylpyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione (57821-19-9) → 7-(4-benzyl-piperazin-1-yl)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / DMF; phosphorus oxychloride / 3 h / 65 °C

2: 40 percent / ethanol / 0.5 h / Heating

With N,N-dimethyl-formamide; trichlorophosphate; In ethanol;

DOI:10.1016/j.bmc.2005.12.008

Reference yield:

6-Ethoxycarbonyl-1,3-dimethylpyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione (57821-19-9) → 1,3-dimethyl-7-[4-(4-nitro-benzyl)-piperazin-1-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / DMF; phosphorus oxychloride / 3 h / 65 °C

2: 52 percent / ethanol / 0.5 h / Heating

With N,N-dimethyl-formamide; trichlorophosphate; In ethanol;

DOI:10.1016/j.bmc.2005.12.008

upstream raw materials:

diethyl malonate

1,3-dimethyl-5-cyanouracil