24410-21-7

Upstream product

• 77-78-1 dimethyl sulfate 
• 21038-66-4 1H-Pyrido[2,3-d]pyrimidine-2,4-dione 
• 16044-79-4 5,7-Dimethylpyrimido<4.5-e>-1,2,4-triazinedione, isofervenulin 
• 94154-88-8 1,3-Dimethyl-4-propargylaminouracil 
• 121-44-8 triethylamine 
• 67-64-1 acetone 
• 105-53-3 diethyl malonate 
• 36980-91-3 1,3-dimethyl-5-cyanouracil 
• 112734-83-5 5-chloro-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione 
• 6972-27-6 1,3-Dimethyl-6-chlorouracil 
• 109-92-2 ethyl vinyl ether 
• 109-89-7 diethylamine 
• 99934-00-6 5-allyl-6-amino-1,3-dimethyl-1H-pyrimidine-2,4-dione 
• 142169-13-9 C₁₅H₁₈N₆O₄ 

Relevant academic research and scientific papers

Bronchodilating pyrido?2,3-d!pyrimidine derivatives

A rapid-acting remedy for asthma having a bronchodilating action contains at least one pyrido?2,3-d!pyrimidine derivative represented by the general formula (A) or pharmaceutically acceptable salts or metal complexes thereof as an effective component: STR1 wherein R1 and R2 are the same or different and each of R1 and R2 is hydrogen, alkyl or benzyl; R3 is hydrogen, hydroxyl, dialkylaminomethyleneamino or --NH--X; X is hydrogen, alkyl, alkenyl, hydroxyl, amino, hydroxyalkyl, benzyl or acyl; R4 is hydrogen, alkyl, halogen, nitro, amino, hydroxyl, benzyloxy, cyano, carboxyl, alkoxycarbonyl, alkoxysulfonyl, aminosulfonyl, dialkylaminosulfonyl or sulfo; and R5 is hydrogen, alkyl or amino. The rapid-acting remedy for bronchial asthma is capable of relieving the symptom of laboring breath at the onset of asthma due to its excellent bronchodilating action. It can be used as a therapy not only for allergic asthma but also for various bronchial asthmas such as endogenous asthma, exogenous asthma and dust asthma.

PYRIMIDINES, XXXII: SYNTHESIS AND PROPERTIES OF PYRIDOPYRIMIDINE-2,4-DIONES (5-DEAZALUMAZINES)

Pyridopyrimidine-2,4-dione (8) and its N-methyl derivatives (9-11) as well as the corresponding 6-nitro analogues (12-15) have been synthesized by condensation reactions from 6-aminouracils (4-7).Reduction of compound (4-7) led to the 6-aminopyrido

DIETHYLAMINE AND TRIETHYLAMINE AS SOURCES OF THE DIENOPHILE COMPONENT IN THE REVERSE AZADIENE SYNTHESIS WITH DIMETHYLPYRIMIDO- AND --1,2,4-TRIAZINEDIONES AND 1,2,4,5-TETRAZINES

Diethylamine (DEA) and triethylamine (TEA) can function as sources for the two-carbon component in the reverse azadiene synthesis.Reaction of 5,7-dimethylpyrimido-1,2,4-triazene-6,8-dione, 6,8-dimethylpyrimido--1,2,4-triazine-5,7-dione, or 1

SYNTHESIS OF PYRIDOPYRIMIDINE-2,4-DIONES FROM PYRIMIDO-1,2,4-TRIAZINE-6,8-DIONES BY REVERSED AZADIENE SYNTHESIS

It as shown that pyrimido-1,2,4-triazine-6,8-diones enter the reversed azadiene synthesis reaction with ketones and vinyl ethyl ether in the presence of diethylamine or boron trifluoride etherate, and also with enamines.As a result of the reaction, pyridopyrimidine-2,4-diones are formed in good yield.Pyrimido-1,2,4-triazine-5,7-diones do not undergo such reactions with acetone.The reasons for the unique behavior of the isomeric pyrimidotriazinediones in the reaction with acetone are discussed.

5-substituted pyrido[2,3-d]pyrimidine-2,4-diones

The present invention relates to a novel pyrido[2,3-d]pyrimidine derivative having the formula (I): STR1 wherein each of R1 and R2, which may be the same or different, is a lower alkyl group; and each of R3 and R4, which may be the same or different, is hydrogen, halogen, hydroxy, nitro, amino, hydroxyamino, hydrazino, azido, a lower alkenylamino group or a lower alkylamino group which may optionally have hydroxy; and pharmaceutically acceptable salt thereof. These compounds are useful as anti-allergic agents, for example, for the treatment of bronchial asthma, urticaria, allergic rhinitis, allergic dermatoses or allergic conjunctivitis.