1-Piperidinecarboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-(dimethylamino)-2-(4-fluoro- 2-methylphenyl)-N-methyl-, (2R,4R)-

Base Information

Chemical Name:1-Piperidinecarboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-(dimethylamino)-2-(4-fluoro- 2-methylphenyl)-N-methyl-, (2R,4R)-
CAS No.:578710-98-2
Molecular Formula:C₂₅H₂₈F₇N₃O
Molecular Weight:519.506
Hs Code.:

Synonyms:

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Chemical Property of 1-Piperidinecarboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-(dimethylamino)-2-(4-fluoro- 2-methylphenyl)-N-methyl-, (2R,4R)-

Chemical Property:

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Technology Process of 1-Piperidinecarboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-(dimethylamino)-2-(4-fluoro- 2-methylphenyl)-N-methyl-, (2R,4R)-

There total 6 articles about 1-Piperidinecarboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-(dimethylamino)-2-(4-fluoro- 2-methylphenyl)-N-methyl-, (2R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 414910-14-8
(2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide

: 124-40-3
dimethyl amine

: 578711-00-9
C₂₅H₂₈F₇N₃O

: 578710-98-2
C₂₅H₂₈F₇N₃O

Guidance literature:: With sodium tris(acetoxy)borohydride; In acetonitrile; at 20 ℃; for 24h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/jm1013264

Reference yield:

: 620-08-6,1232006-56-2
4-methoxypyridine

: 578711-00-9
C₂₅H₂₈F₇N₃O

: 578710-98-2
C₂₅H₂₈F₇N₃O

Guidance literature:: Multi-step reaction with 6 steps

1.1: iodine; magnesium / tetrahydrofuran / 35 - 70 °C / Inert atmosphere; Reflux; Large scale reaction

1.2: -20 - 30 °C / Inert atmosphere; Large scale reaction

2.1: Wilkinson's catalyst; hydrogen / isopropyl alcohol / 5 h / 50 - 60 °C / 3750.38 Torr / Inert atmosphere; Large scale reaction

3.1: 5% Pd(II)/C(eggshell); hydrogen / isopropyl alcohol / 5 h / 20 °C / 3000.3 Torr / Inert atmosphere; Large scale reaction

3.2: Inert atmosphere; Large scale reaction

4.1: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / Inert atmosphere; Large scale reaction

4.2: 20 °C / Inert atmosphere; Large scale reaction

5.1: sodium hydrogencarbonate / water; ethyl acetate / 0.25 h / 20 °C / Inert atmosphere

5.2: 3 h / 0 - 20 °C / Inert atmosphere

5.3: 2 h / 20 °C / Inert atmosphere

6.1: sodium tris(acetoxy)borohydride / acetonitrile / 24 h / 20 °C / Inert atmosphere

With Wilkinson's catalyst; 5% Pd(II)/C(eggshell); hydrogen; iodine; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; magnesium; In tetrahydrofuran; dichloromethane; water; ethyl acetate; isopropyl alcohol; acetonitrile; 1.2: Comins type reaction;
DOI:10.1021/jm1013264

Reference yield:

: 414909-98-1
phenylmethyl 2-(4-fluoro-2-methylphenyl)-4-oxo-3,4-dihydro-1(2H)-pyridinecarboxylate

: 578711-00-9
C₂₅H₂₈F₇N₃O

: 578710-98-2
C₂₅H₂₈F₇N₃O

Guidance literature:: Multi-step reaction with 5 steps

1.1: Wilkinson's catalyst; hydrogen / isopropyl alcohol / 5 h / 50 - 60 °C / 3750.38 Torr / Inert atmosphere; Large scale reaction

2.1: 5% Pd(II)/C(eggshell); hydrogen / isopropyl alcohol / 5 h / 20 °C / 3000.3 Torr / Inert atmosphere; Large scale reaction

2.2: Inert atmosphere; Large scale reaction

3.1: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / Inert atmosphere; Large scale reaction

3.2: 20 °C / Inert atmosphere; Large scale reaction

4.1: sodium hydrogencarbonate / water; ethyl acetate / 0.25 h / 20 °C / Inert atmosphere

4.2: 3 h / 0 - 20 °C / Inert atmosphere

4.3: 2 h / 20 °C / Inert atmosphere

5.1: sodium tris(acetoxy)borohydride / acetonitrile / 24 h / 20 °C / Inert atmosphere

With Wilkinson's catalyst; 5% Pd(II)/C(eggshell); hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; In dichloromethane; water; ethyl acetate; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm1013264