Technology Process of N-[2-(dimethylamino)ethyl]-2-phenylquinoline-8-carboxamide
There total 10 articles about N-[2-(dimethylamino)ethyl]-2-phenylquinoline-8-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 39 percent / methanesulfonic acid / benzene / 36 h / Heating
2: 35 percent / various solvent(s) / 255 °C
3: 98 percent / KOH / aq. ethanol / 2 h / Heating
4: 1.) KOH, Al-foil, 2) HCl, FeCl3 / 1.) 50percent aq. EtOH, 2.) reflux, 30 min
5: 1.) 1,1'-carbonyldiimidazole, 3.) conc. HCl / 1.) DMF, 20 to 40 deg C, 20 min, 2.) 20 deg C, 15 min
With
hydrogenchloride; potassium hydroxide; methanesulfonic acid; iron(III) chloride; 1,1'-carbonyldiimidazole; aluminium;
In
ethanol; benzene;
DOI:10.1021/jm00122a018
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 20 percent / ethanol / 3 h / Heating
2: 93 percent / Cu-powder / 280 - 290 °C
3: 34 percent / SeO2 / a) 180 to 190 deg C, b) 280 to 290 deg C, 2 min
4: 1.) 1,1'-carbonyldiimidazole, 3.) conc. HCl / 1.) DMF, 20 to 40 deg C, 20 min, 2.) 20 deg C, 15 min
With
hydrogenchloride; selenium(IV) oxide; copper; 1,1'-carbonyldiimidazole;
In
ethanol;
DOI:10.1021/jm00122a018
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 39 percent / methanesulfonic acid / benzene / 36 h / Heating
2: 35 percent / various solvent(s) / 255 °C
3: 98 percent / KOH / aq. ethanol / 2 h / Heating
4: 1.) KOH, Al-foil, 2) HCl, FeCl3 / 1.) 50percent aq. EtOH, 2.) reflux, 30 min
5: 1.) 1,1'-carbonyldiimidazole, 3.) conc. HCl / 1.) DMF, 20 to 40 deg C, 20 min, 2.) 20 deg C, 15 min
With
hydrogenchloride; potassium hydroxide; methanesulfonic acid; iron(III) chloride; 1,1'-carbonyldiimidazole; aluminium;
In
ethanol; benzene;
DOI:10.1021/jm00122a018