Chemical Property of 2-Aminoethyl diphenylborinate
Chemical Property:
- Appearance/Colour:White crystalline powder
- Vapor Pressure:0.000232mmHg at 25°C
- Melting Point:192-194 °C(lit.)
- Refractive Index:1.559
- Boiling Point:325.3 °C at 760 mmHg
- PKA:8.03±0.10(Predicted)
- Flash Point:150.6 °C
- PSA：35.25000
- Density:1.04 g/cm3
- LogP:1.46790
- Storage Temp.:2-8°C
- Solubility.:Soluble in ethanol and methanol.
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:5
- Exact Mass:225.1324943
- Heavy Atom Count:17
- Complexity:182
- Purity/Quality:
-
≥99% *data from raw suppliers
2-APB *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
36/37/38
- Safety Statements:
22-24/25
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Chemical Classes:Metals -> Metalloid Compounds (Boron)
- Canonical SMILES:B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN
-
Description
2-Aminoethyl diphenylborinate (2-APB) is a modulator of intracellular calcium levels and transient receptor potential (TRP) channels. It inhibits calcium release induced by inositol-1,4,5-triphosphate (IP3) in rat cerebellar microsomes (IC50 = 42 μM) without affecting IP3 binding to its receptor. 2-APB inhibits store-operated calcium entry (SOCE) in DT40 cells (IC50 = 4.8 μM), as well as inhibits TRP canonical 6 (TRPC6) and TRP melastatin 8 (TRPM8) and activates TRP vanilloid 1 (TRPV1), TRPV2, and TRPV3 in vitro. It also inhibits calcium transients induced by the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor thapsigargin in DDT1 MF-2 cells when used at a concentration of 75 μM. 2-APB inhibits differentiation of primary mouse brown adipocytes when used at concentrations ranging from 30 to 300 μM and reduces adipocyte triglyceride levels at 100 μM. It also increases the expression of Ucp1 and Pparg in primary mouse brown adipocytes. 2-APB (10 mg/kg) reduces protein levels of TRP melastatin 2 (TRPM2) in the rat hippocampus and improves learning and memory deficits induced by amyloid-β (25-35) in rats.
-
Uses
Ca release inhibitor, angiogensin II inhibitor 2-Aminoethyl diphenylborinate is used for the densitometric determination of flavonoids and TRP activator. It is also used to manipulate intracellular release of calcium ions and in preparation of apoptotic inducers. It serves as a reactant for preparation of apoptotic inducers and in membrane-permeable SOCE (store operated calcuym entry) inhibitor.
