Methanone, (2-methylphenyl)-3-pyridinyl-

Base Information

• Chemical Name: Methanone, (2-methylphenyl)-3-pyridinyl-
• CAS No.: 59190-59-9
• Molecular Formula: C13H11NO
• Molecular Weight: 197.236
• Mol file: 59190-59-9.mol

Synonyms:pyridin-3-yl-o-tolyl-methanone;2-Methylphenyl-3-pyridylmethanon;o-tolyl-3-pyridylmethanone;Methanone, (2-methylphenyl)-3-pyridinyl-;

Chemical Property of Methanone, (2-methylphenyl)-3-pyridinyl-

Chemical Property:

• PSA: 29.96000
• LogP: 2.62100

Purity/Quality:

95% ^*data from raw suppliers

Pyridin-3-yl(o-tolyl)methanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanone, (2-methylphenyl)-3-pyridinyl-

There total 5 articles about Methanone, (2-methylphenyl)-3-pyridinyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-iodopyridine (1120-90-7) + carbon monoxide (201230-82-2) + 2-Methylphenylboronic acid (16419-60-6) → pyridin-3-yl(o-tolyl)methanone (59190-59-9)

Guidance literature:

3-iodopyridine; 2-Methylphenylboronic acid; With potassium carbonate; In toluene; for 0.166667h; Autoclave;

carbon monoxide; In toluene; at 100 ℃; for 10h; under 10343.2 Torr; Autoclave;

DOI:10.1055/s-0030-1258349

Reference yield:

3-pyridinecarboxaldehyde (500-22-1) + 2-methylphenyl bromide (95-46-5) → pyridin-3-yl(o-tolyl)methanone (59190-59-9)

Guidance literature:

2-methylphenyl bromide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

3-pyridinecarboxaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h;

With dipyridinium dichromate; In dichloromethane; at 20 ℃; for 3h;

DOI:10.3390/molecules24030401

Reference yield:

3-Bromopyridine (626-55-1,163928-56-1) + carbon monoxide (201230-82-2) + 2-Methylphenylboronic acid (16419-60-6) → 3-(p-methylphenyl)pyridine (90395-49-6) + pyridin-3-yl(o-tolyl)methanone (59190-59-9)

Guidance literature:

With caesium carbonate; 1,3-bis(mesityl)imidazolium chloride; palladium diacetate; In 1,4-dioxane; at 120 ℃; for 30h; under 37503 Torr;

DOI:10.1016/j.tet.2006.11.008

upstream raw materials:

3-Bromopyridine

carbon monoxide

2-Methylphenylboronic acid

3-iodopyridine

Downstream raw materials:

[3]Pyridyl-o-tolyl-methanol

(S)-pyridin-3-yl(o-tolyl)methanol

(R)-pyridin-3-yl(o-tolyl)methanol