Benzamide, N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperidin ylmethyl)-

Base Information

Chemical Name:Benzamide, N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperidin ylmethyl)-
CAS No.:593281-60-8
Molecular Formula:C29H30N6O
Molecular Weight:478.597
Hs Code.:

Synonyms:

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Chemical Property of Benzamide, N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperidin ylmethyl)-

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of Benzamide, N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperidin ylmethyl)-

There total 11 articles about Benzamide, N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperidin ylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.6%

: 110-89-4
piperidine

: 404844-11-7
4-(chloromethyl)-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]-amino}phenyl)benzamide

: 593281-60-8
N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperidin-1-ylmethyl)benzamide

Guidance literature:: for 3h; Inert atmosphere; Schlenk technique; Reflux;
DOI:10.1021/op700270n

Reference yield:

: 152460-10-1
6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

: 593281-60-8
N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperidin-1-ylmethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere; Schlenk technique

1.2: 3.17 h / 0 °C / Inert atmosphere; Schlenk technique

2.1: 3 h / Inert atmosphere; Schlenk technique; Reflux

With triethylamine; In tetrahydrofuran;
DOI:10.1021/op700270n

Reference yield:

: 350-03-8
methyl-3-pyridylketone

: 593281-60-8
N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperidin-1-ylmethyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 5,5-dimethyl-1,3-cyclohexadiene / 20 h / 140 °C / Inert atmosphere; Schlenk technique

2.1: sodium hydroxide / butan-1-ol / 12 h / Inert atmosphere; Schlenk technique; Reflux

3.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 20 h / 20 - 100 °C / Inert atmosphere; Schlenk technique

4.1: hydrazine hydrate; iron(III) chloride; pyrographite / water / 80 °C / Inert atmosphere; Schlenk technique

5.1: triethylamine / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere; Schlenk technique

5.2: 3.17 h / 0 °C / Inert atmosphere; Schlenk technique

6.1: 3 h / Inert atmosphere; Schlenk technique; Reflux

With iron(III) chloride; copper(l) iodide; potassium carbonate; pyrographite; hydrazine hydrate; triethylamine; sodium hydroxide; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1,4-dioxane; 5,5-dimethyl-1,3-cyclohexadiene; water; butan-1-ol; 3.1: |Ullmann Condensation;
DOI:10.1021/op700270n