Chemical Property of Ganaxolone
Chemical Property:
- Vapor Pressure:2.19E-09mmHg at 25°C
- Melting Point:190-192°
- Boiling Point:434.8°Cat760mmHg
- PKA:15.18±0.70(Predicted)
- Flash Point:185.4°C
- PSA：37.30000
- Density:1.036g/cm3
- LogP:4.98530
- Storage Temp.:2-8°C
- Solubility.:DMSO: ~4.2 mg/mL
- XLogP3:5
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:1
- Exact Mass:332.271530387
- Heavy Atom Count:24
- Complexity:542
- Purity/Quality:
-
99% *data from raw suppliers
Ganaxolone *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
22-24/25
- MSDS Files:
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Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CC(=O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)(C)O)C)C
- Isomeric SMILES:CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@@](C4)(C)O)C)C
- Recent ClinicalTrials:A Clinical Trial of Intravenous (IV) Ganaxolone in Women With Postpartum Depression
- Recent EU Clinical Trials:A double-blind, randomized, placebo-controlled trial of adjunctive ganaxolone treatment in female children with protocadherin 19 (PCDH19)-related epilepsy followed by long-term open-label treatment
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Description
Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABAA receptor current. At nanomolar concentrations, it can potentiate GABA-evoked currents at GABAA receptor complexes containing α1, α2, α3, β2, and γ2L subunits expressed in Xenopus oocytes. Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials.
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Uses
Treatment of epilepsy and migraine. Ganaxolone, is synthetic neuroactive steroid, which possess sedative, anxiolytic, and anticonvulsant properties. It is also a potent and selective positive allosteric modulator of GABAA receptors. It is also shown to be used for the treatment of epilepsy.
