6-chloro -4-phenyl quinazoline-2-carboxylic acid

Base Information

• Chemical Name: 6-chloro -4-phenyl quinazoline-2-carboxylic acid
• CAS No.: 5958-08-7
• Molecular Formula: C15H9ClN2O2
• Molecular Weight: 284.702
• Hs Code.: 2933990090
• Mol file: 5958-08-7.mol

Synonyms:6-chloro-4-phenylquinazoline-2-carboxylic acid;

Chemical Property of 6-chloro -4-phenyl quinazoline-2-carboxylic acid

Chemical Property:

• PSA: 63.08000
• LogP: 3.64840
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

6-Chloro-4-phenylquinazoline-2-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloro -4-phenyl quinazoline-2-carboxylic acid

There total 7 articles about 6-chloro -4-phenyl quinazoline-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

6-chloro-1,2-dihydro-4-phenylquinazoline-2-carboxylic acid (153681-82-4) → 6-chloro-4-phenylquinazoline-2-carboxylic acid (5958-08-7)

Guidance literature:

With air; In N,N-dimethyl-formamide; for 72h; Irradiation;

DOI:10.1016/S0040-4020(01)80432-4

Reference yield: 16.0%

6-chloro-4-phenylquinazoline-2-carbonitrile (51483-21-7) → 6-chloro-4-phenylquinazoline-2-carboxylic acid (5958-08-7)

Guidance literature:

With water; sodium hydroxide; at 80 ℃; for 3h;

Reference yield:

5-chloro-2-aminobenzophenone (719-59-5) → 6-chloro-4-phenylquinazoline-2-carboxylic acid (5958-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent Turnov_. / ammonium acetate / H₂O; ethanol / 0.25 h

2: 87 percent / air / dimethylformamide / 72 h / Irradiation

With ammonium acetate; air; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)80432-4

upstream raw materials:

6-chloro-3,4-dihydro-4-phenylquinazoline-2-carboxylic acid

6-chloro-1,2-dihydro-4-phenylquinazoline-2-carboxylic acid

5-chloro-2-aminobenzophenone

6-chloro-4-phenylquinazoline-2-carbonitrile

Downstream raw materials:

6-chloro-4-phenylquinazoline-2-carboxamide

6-chloro-N-methyl-4-phenylquinazoline-2-carboxamide

N-benzyl-6-chloro-4-phenylquinazoline-2-carboxamide

N-benzyl-6-chloro-N-ethyl-4-phenylquinazoline-2-carboxamide

Refernces

• 1、 Castellano, Sabrina,Taliani, Sabrina,Viviano, Monica,Milite, Ciro,Da Pozzo, Eleonora,Costa, Barbara,Barresi, Elisabetta,Bruno, Agostino,Cosconati, Sandro,Marinelli, Luciana,Greco, Giovanni,Novellino, Ettore,Sbardella, Gianluca,Da Settimo, Federico,Martini, Claudia. "Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors". . p. 2413 - 2428. Retrieved 2014/04/17.
• 2、 Hoefnagel,Van Koningsveld,Van Meurs,Peters,Sinnema,Van Bekkum. "Reactions of hydroxyglycines. New synthetic routes to 4-phenylquinazoline derivatives". . p. 6899 - 6912. Retrieved 2007/10/02.