153681-82-4 Usage
Description
6-chloro-4-phenyl-1,2-dihydroquinazoline-2-carboxylic acid is a heterocyclic compound characterized by a quinazoline ring, a chloro group, a phenyl group, and a carboxylic acid group. It possesses unique chemical properties due to the presence of these functional groups, making it a promising candidate for pharmaceutical applications, particularly in medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
6-chloro-4-phenyl-1,2-dihydroquinazoline-2-carboxylic acid is used as a potential pharmaceutical compound for its unique chemical properties and potential applications in medicinal chemistry. The chloro and phenyl groups provide distinct characteristics, while the carboxylic acid group offers opportunities for drug delivery and controlled release.
Used in Drug Development:
6-chloro-4-phenyl-1,2-dihydroquinazoline-2-carboxylic acid is used as a starting material or intermediate in the synthesis of various pharmaceutical agents. Its complex structure and functional groups make it a valuable component in the development of new drugs with specific therapeutic properties.
Used in Medicinal Chemistry Research:
6-chloro-4-phenyl-1,2-dihydroquinazoline-2-carboxylic acid is used as a subject of study in medicinal chemistry research to explore its potential as a therapeutic agent or as a building block for the design of novel pharmaceutical compounds. Its unique structure and properties make it an interesting target for further investigation and development.
Check Digit Verification of cas no
The CAS Registry Mumber 153681-82-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,6,8 and 1 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 153681-82:
(8*1)+(7*5)+(6*3)+(5*6)+(4*8)+(3*1)+(2*8)+(1*2)=144
144 % 10 = 4
So 153681-82-4 is a valid CAS Registry Number.
153681-82-4Relevant articles and documents
Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors
Castellano, Sabrina,Taliani, Sabrina,Viviano, Monica,Milite, Ciro,Da Pozzo, Eleonora,Costa, Barbara,Barresi, Elisabetta,Bruno, Agostino,Cosconati, Sandro,Marinelli, Luciana,Greco, Giovanni,Novellino, Ettore,Sbardella, Gianluca,Da Settimo, Federico,Martini, Claudia
, p. 2413 - 2428 (2014/04/17)
Structure-activity relationships (SARs) within the 4-phenylquinazoline-2- carboxamide series of translocator protein (TSPO) ligands have been explored further by the synthesis and TSPO binding affinity evaluation of N-benzyl-N-ethyl/methyl derivatives var
Reactions of hydroxyglycines. New synthetic routes to 4-phenylquinazoline derivatives
Hoefnagel,Van Koningsveld,Van Meurs,Peters,Sinnema,Van Bekkum
, p. 6899 - 6912 (2007/10/02)
Reaction of hydroxyglycine with 2-aminobenzophenones gives 1,2-dihydro-4-phenyl-quinazoline-2-carboxylic acids in high yields and under mild conditions. These can be smoothly converted into the corresponding 3,4-dihydro isomers and into quinazoline derivatives via rearrangement and oxidation by air, respectively. The X-ray crystallographic structure of 6-chloro-1,2-dihydro-1-methyl-4-phenylquinazoline-2-carboxylic acid shows the carboxylate group at C(2) and the methyl group at N(1) to be in axial positions.
