Technology Process of METHYL 2,3-DICHLOROISONICOTINATE
There total 1 articles about METHYL 2,3-DICHLOROISONICOTINATE which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,3-dichloroisonicotinic acid;
With
oxalyl dichloride;
N,N-dimethyl-formamide;
In
dichloromethane;
at 20 ℃;
for 18h;
methanol;
In
dichloromethane; toluene;
at 0 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: dichloro[2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]palladium(II); N-ethyl-N,N-diisopropylamine / 12 h / 100 °C / 1140.08 - 1520.1 Torr / Inert atmosphere; Schlenk technique; Sealed tube
2: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; pyridine / toluene / 190 °C / Inert atmosphere; Microwave irradiation; Sealed tube
3: lithium hydroxide / water; methanol / 0 - 20 °C
With
pyridine; dichloro[2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]palladium(II); palladium diacetate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hydroxide;
In
methanol; water; toluene;
2: |Buchwald-Hartwig Coupling;
DOI:10.1002/cmdc.202000147
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dichloro[2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]palladium(II); N-ethyl-N,N-diisopropylamine / 12 h / 100 °C / 1140.08 - 1520.1 Torr / Inert atmosphere; Schlenk technique; Sealed tube
2: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; pyridine / toluene / 190 °C / Inert atmosphere; Microwave irradiation; Sealed tube
With
pyridine; dichloro[2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]palladium(II); palladium diacetate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
toluene;
2: |Buchwald-Hartwig Coupling;
DOI:10.1002/cmdc.202000147
