4-Phenyl-3,4-dihydroquinolin-2(1h)-one

Base Information

• Chemical Name: 4-Phenyl-3,4-dihydroquinolin-2(1h)-one
• CAS No.: 4888-33-9
• Molecular Formula: C15H13NO
• Molecular Weight: 223.274
• NSC Number: 116961
• DSSTox Substance ID: DTXSID70297627
• Nikkaji Number: J1.586.104E
• Mol file: 4888-33-9.mol

Synonyms:4-phenyl-3,4-dihydroquinolin-2(1h)-one;4888-33-9;4-phenyl-3,4-dihydro-1H-quinolin-2-one;3,4-DIHYDRO-4-PHENYL-2(1H)-QUINOLINONE;4-Phenyl-3,4-dihydro-2(1H)-quinolinone;NSC116961;SCHEMBL880376;4-phenyl-3,4-dihydrocarbostyril;DTXSID70297627;DEJKVLIJTMGIIR-UHFFFAOYSA-N;AB50313;NSC-116961

Chemical Property of 4-Phenyl-3,4-dihydroquinolin-2(1h)-one

Chemical Property:

• Vapor Pressure: 2.14E-06mmHg at 25°C
• Melting Point: 180-181℃
• Boiling Point: 393.4°Cat760mmHg
• Flash Point: 236.3°C
• PSA: 29.10000
• Density: 1.156g/cm³
• LogP: 3.29870
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 223.099714038
• Heavy Atom Count: 17
• Complexity: 283

Purity/Quality:

98%min ^*data from raw suppliers

4-Phenyl-3,4-dihydroquinolin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C2=CC=CC=C2NC1=O)C3=CC=CC=C3

Technology Process of 4-Phenyl-3,4-dihydroquinolin-2(1h)-one

There total 60 articles about 4-Phenyl-3,4-dihydroquinolin-2(1h)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-phenylcinnamamide (3056-73-3) → 4-phenyl-3,4-dihydro-1H-quinolin-2-one (4888-33-9)

Guidance literature:

With HUSY; In 1,2-dichloro-benzene; at 190 ℃; for 27h;

DOI:10.1039/b404074k

Reference yield: 96.0%

carbon monoxide (201230-82-2) + 2-(1-phenylvinyl)aniline (64097-92-3) → 4-phenyl-3,4-dihydro-1H-quinolin-2-one (4888-33-9)

Guidance literature:

With hydrogen; 1,4-di(diphenylphosphino)-butane; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; at 120 ℃; for 45h; under 31028.9 Torr;

DOI:10.1002/adsc.200606100

Reference yield: 85.0%

C17H15NO4 → 4-phenyl-3,4-dihydro-1H-quinolin-2-one (4888-33-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 22 ℃; for 16h;

DOI:10.1021/acs.orglett.8b01015

upstream raw materials:

4-phenyl-2-quinolinone

N-phenylcinnamamide

phenyl 3-chloro-3-phenylpropanamide

(2E)-N-(2-chlorophenyl)cinnamamide

Downstream raw materials:

2-chloro-3-morpholin-4-ylmethylene-4-phenyl-3,4-dihydro-quinoline

1-tert-Butoxycarbonyl-4-phenyl-3,4-dihydrocarbostyril

4-phenyl-3,4-dihydro-1H-quinoline-2-thione

4-phenyl-3,4-dihydroquinolin-2-ylamine