1H-Isoindole-1-carboxylic acid, 2,3-dihydro-, Methyl ester, hydrochloride

Base Information

• Chemical Name: 1H-Isoindole-1-carboxylic acid, 2,3-dihydro-, Methyl ester, hydrochloride
• CAS No.: 60651-97-0
• Molecular Formula: C10H11NO2.ClH
• Molecular Weight: 213.664
• Hs Code.: 2933990090
• Mol file: 60651-97-0.mol

Synonyms:1,3-dihydro-isoindol-4-ylamine;2,3-Dihydro-1H-isoindol-4-ylamine;Methyl 1,3-dihydro-2H-isoindole-1-carboxylate Hydrochloride;4-aminoisoindoline;Isoindolin-4-amine;4-Amino-isoindolin;1H-Isoindol-4-amine,2,3-dihydro;

Chemical Property of 1H-Isoindole-1-carboxylic acid, 2,3-dihydro-, Methyl ester, hydrochloride

Chemical Property:

• Melting Point: 159-161 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
• PSA: 38.33000
• LogP: 2.13470

Purity/Quality:

2,3-DIHYDRO-1H-ISOINDOLE-1-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Isoindole-1-carboxylic acid, 2,3-dihydro-, Methyl ester, hydrochloride

There total 2 articles about 1H-Isoindole-1-carboxylic acid, 2,3-dihydro-, Methyl ester, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methanol (67-56-1) + 1,3-Dihydro-2H-isoindole-1-carboxylic Acid Hydrochloride (96016-96-5) → Methyl 1,3-dihydro-2H-isoindole-1-carboxylate Hydrochloride (60651-97-0)

Guidance literature:

With thionyl chloride; at 0 - 27 ℃; for 16h;

Reference yield:

3-(acetylthio)propanoyl chloride (41345-72-6) + octahydro-1H-isoindole-1-carboxylic acid hydrochloride (108395-22-8) → Methyl 1,3-dihydro-2H-isoindole-1-carboxylate Hydrochloride (60651-97-0) + octahydro-2-[3-(acetylthio)propanoyl]-1H-isoindole-1-carboxylic acid (108395-31-9)

Guidance literature:

With pyridine; In tetrahydrofuran; water;

Reference yield: 93.0%

Methyl 1,3-dihydro-2H-isoindole-1-carboxylate Hydrochloride (60651-97-0) → 1,3-Dihydro-2H-isoindole-1-carboxylic Acid Hydrochloride (96016-96-5)

Guidance literature:

With sodium hydroxide; at 100 ℃; for 30h;

upstream raw materials:

3-(acetylthio)propanoyl chloride

octahydro-1H-isoindole-1-carboxylic acid hydrochloride

methanol

1,3-Dihydro-2H-isoindole-1-carboxylic Acid Hydrochloride

Downstream raw materials:

1,3-Dihydro-2H-isoindole-1-carboxylic Acid Hydrochloride

Methyl 1,3-Dihydro-2-benzoyl-2H-isoindole-1-carboxylate

Methyl 1,3-Dihydro-2-phenylacetyl-2H-isoindole-1-carboxylate

2-Benzoyl-1,3-dihydro-2H-isoindole-1-carboxylic Acid

Refernces

• 1、 -. "SUBSTITUTED ACYL DERIVATIVES OF OCTAHYDRO-1H-ISOINDOLE-1-CARBOXYLIC ACIDS". . . Retrieved 2008/06/13.