96016-96-5

Usage

Uses

Used in Pharmaceutical Industry:
2,3-DIHYDRO-1H-ISOINDOLE-1-CARBOXYLIC ACID HYDROCHLORIDE is used as a pharmaceutical compound for its potential applications in the treatment of central nervous system disorders. Its ability to act as a ligand for various receptors and ion channels in the brain makes it a valuable candidate for the development of new drugs for neurological and psychiatric conditions.
Used in Research and Development:
2,3-DIHYDRO-1H-ISOINDOLE-1-CARBOXYLIC ACID HYDROCHLORIDE is used as a research compound in the pharmaceutical industry. Its unique properties and potential applications in the field of central nervous system disorders make it a valuable tool for scientists and researchers working on the development of new drugs and therapies for neurological and psychiatric conditions.

Upstream product

• 60651-97-0 Methyl 1,3-dihydro-2H-isoindole-1-carboxylate Hydrochloride 
• 1367468-00-5 tert-butyl (+/-)-1-cyano-1,3-dihydro-2H-isoindole-2-carboxylate 
• 480-91-1 oxisoindole 
• 221352-46-1 2-(tert-butoxycarbonyl)isoindoline-1-carboxylic acid 
• 1367467-98-8 tert-butyl (+/-)-1-methoxy-1,3-dihydro-2H-isoindole-2-carboxylate 
• 1367467-96-6 tert-butyl (+/-)-1-hydroxy-1,3-dihydro-2H-isoindole-2-carboxylate 

Downstream Products

• 111605-85-7 methyl (+/-)-1,3-dihydro-2H-isoindole-1-carboxylate 
• 96325-09-6 2-benzyl 1-methyl (+/-)-1,3-dihydro-2H-isoindole-1,2-dicarboxylate 
• 96325-10-9 (+/-)-2-[(benzyloxy)carbonyl]-1,3-dihydro-2H-isoindole-1-carboxylic acid 
• 1367468-10-7 (R)-2-benzyl 1-methyl 1,3-dihydro-2H-isoindole-1,2-dicarboxylate 
• 1367468-16-3 C₂₀H₁₈F₃NO₄ 
• 1367468-14-1 C₂₀H₁₈F₃NO₄ 
• 781597-60-2 methyl (S)-1,3-dihydro-2H-isoindole-1-carboxylate 
• 1367468-12-9 methyl (R)-1,3-dihydro-2H-isoindole-1-carboxylate 
• 444607-92-5 2-(tert-butyl) 1-methyl isoindoline-1,2-dicarboxylate 
• 60651-97-0 Methyl 1,3-dihydro-2H-isoindole-1-carboxylate Hydrochloride 

Relevant academic research and scientific papers

Stereospecific ring-expanding skeletal rearrangement of isoindoline to tetrahydroisoquinoline via a sequential aziridine ring formation/opening

A stereospecific skeletal rearrangement of isoindoline to tetrahydroisoquinoline was developed under Appel reaction conditions using a combination of PPh3 and CCl4. This reaction involves a sequential ring formation/opening of a labile aziridine and enables the construction of a quaternary carbon center, offering a highly useful method for accessing 3,3,4-trisubstituted tetrahydroisoquinolines.

Dynamic kinetic resolution of 1,3-dihydro-2 h-isoindole-1-carboxylic acid methyl ester: Asymmetric transformations toward isoindoline carbamates

Asymmetric syntheses of isoindoline carbamates have been successfully achieved through enzyme-mediated dynamic kinetic resolution processes and without requirement of metal or acid-base catalyst for the substrate racemization. Optically active carbamates

N-arylsulfonyl aryl aza-bicyclic derivatives as potent cell adhesion inhibitors

Compounds of Formula I are antagonists of VLA-4 and/or alpha4/beta7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of AIDS-related dementia, allergic conjunctivitis, allergic rhinitis, Alzheimer's disease, asthma, atherosclerosis, autologous bone marrow transplantation, certain types of toxic and immune-based nephritis, contact dermal hypersensitivity, inflammatory bowel disease including ulcerative colitis and Crohn's disease, inflammatory lung diseases, inflammatory sequelae of viral infections, meningitis, multiple sclerosis, multiple myeloma, myocarditis, organ transplantation, psoriasis, pulmonary fibrosis, restenosis, retinitis, rheumatoid arthritis, septic arthritis, stroke, tumor metastasis, uveititis, and type I diabetes.

Synthesis of the 5H-Pyrroloisoindole Ring with 1,3-Dipolar Cycloaddition Reactions

The 1,3-dipolar cycloaddition reaction between mesoionic oxazolines, formed from either 1,3-dihydro-2-substituted-2H-isoindole-1-carboxylic acids or 1,3-dihydro-1-oxo-α-substituted-2H-isoindole-2-acetic acids, and dimethylacetylene dicarboxylate has led t