Pimonidazole

Base Information

• Chemical Name: Pimonidazole
• CAS No.: 70132-50-2
• Molecular Formula: C11H18 N4 O3
• Molecular Weight: 254.29
• Mol file: 70132-50-2.mol

Synonyms:NSC380540; PD 126675; Pimonidazole; Ro 03-8799

Chemical Property of Pimonidazole

Chemical Property:

• Vapor Pressure: 1.94E-10mmHg at 25°C
• Boiling Point: 490.5°C at 760 mmHg
• PKA: 14.06±0.20(Predicted)
• Flash Point: 250.5°C
• Density: 1.39g/cm³
• Storage Temp.: 2-8°C
• Solubility.: DMSO: >20mg/mL

Purity/Quality:

98%,99%, ^*data from raw suppliers

Pimonidazole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Description: Hypoxic cells are low oxygen cells that when present in tumors are radioresistant and chemoresistant. Pimonidazole is a small molecule radiosensitizer that has proven to be an effective and nontoxic hypoxia marker for human squamous cell carcinomas of the cervix, head, and neck. This immunochemical hypoxia marker has been widely used in experimental and clinical studies due to its chemical stability, water solubility, and wide tissue distribution. It is generally administered in aqueous solution by injection.
• Uses: Pimonidazole is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It labels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.

Technology Process of Pimonidazole

There total 3 articles about Pimonidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

piperidine (110-89-4) + pyrographite (7440-44-0) + α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol (13551-86-5) → Pimonidazole (70132-50-2)

Guidance literature:

In methanol; ethanol; water;

Reference yield: 11.0%

1-oxiranylmethyl-piperidine (4945-53-3,140166-88-7,141671-18-3) + 2-nitro-1H-imidazole (527-73-1) + pyrographite (7440-44-0) → Pimonidazole (70132-50-2)

Guidance literature:

With sodium carbonate; potassium carbonate; In ethanol; water; ethyl acetate;

Reference yield:

→ Pimonidazole (70132-50-2)

Guidance literature:

1-(2,3-Epoxypropyl)-2-nitroimidazol, Piperidin;

upstream raw materials:

piperidine

pyrographite

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

1-oxiranylmethyl-piperidine