Welcome to LookChem.com Sign In|Join Free

CAS

  • or

13551-86-5

Post Buying Request

13551-86-5 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

13551-86-5 Usage

Uses

1-(3-Chloro-2-hydroxypropyl)-2-nitroimidazole is an intermediate in the synthesis of 1-(2,3-Epoxypropyl)-2-nitroimidazole (B592583) which is an intermediate in the synthesis of Pimonidazole-d10 (P447814). Isotope labelled Pimonidazole (P447813) is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It abels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.

Check Digit Verification of cas no

The CAS Registry Mumber 13551-86-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,5,5 and 1 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 13551-86:
(7*1)+(6*3)+(5*5)+(4*5)+(3*1)+(2*8)+(1*6)=95
95 % 10 = 5
So 13551-86-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H8ClN3O3/c7-3-5(11)4-9-2-1-8-6(9)10(12)13/h1-2,5,11H,3-4H2

13551-86-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-chloro-3-(2-nitroimidazol-1-yl)propan-2-ol

1.2 Other means of identification

Product number -
Other names 3-chloro-1-(2-nitro-1-imidazolyl)-2-propanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13551-86-5 SDS

13551-86-5Synthetic route

1-chloro-3-(2-nitro-1H-imidazol-1-yl)propan-2-one
21787-94-0

1-chloro-3-(2-nitro-1H-imidazol-1-yl)propan-2-one

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol
13551-86-5

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 0℃;97%
2-nitro-1H-imidazole
527-73-1

2-nitro-1H-imidazole

epichlorohydrin
106-89-8

epichlorohydrin

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol
13551-86-5

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

Conditions
ConditionsYield
With potassium carbonate for 0.25 - 0.333333h; Heating / reflux;83%
With potassium carbonate for 0.333333h; Reflux;
With potassium carbonate In acetone Heating / reflux;
potassium phtalimide
1074-82-4

potassium phtalimide

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol
13551-86-5

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

2-(2-hydroxy-3-(2-nitro-1H-imidazol-1-yl)propyl)isoindoline-1,3-dione
93272-45-8

2-(2-hydroxy-3-(2-nitro-1H-imidazol-1-yl)propyl)isoindoline-1,3-dione

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 85℃; for 2h;87%
4-(1,2-dicarba-closo-dodecaboran(12)-1-yl)phenyl isocyanate
158565-51-6

4-(1,2-dicarba-closo-dodecaboran(12)-1-yl)phenyl isocyanate

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol
13551-86-5

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

1-(chloromethyl)-2-(2-nitroimidazoly)ethyl N-(4-(1,2-dicarba-closo-dodecaboran(12)-1-yl)phenyl)carbamate
158565-52-7

1-(chloromethyl)-2-(2-nitroimidazoly)ethyl N-(4-(1,2-dicarba-closo-dodecaboran(12)-1-yl)phenyl)carbamate

Conditions
ConditionsYield
In toluene refluxed for 24 h; evapd., the residue is recrystd. (chloroform);81%
4-amino-1-butyne hydrochloride
88211-50-1

4-amino-1-butyne hydrochloride

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol
13551-86-5

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

1-but-3-ynylamino-3-(2-nitro-imidazol-1-yl)-propan-2-ol
1021880-41-0

1-but-3-ynylamino-3-(2-nitro-imidazol-1-yl)-propan-2-ol

Conditions
ConditionsYield
With potassium carbonate In methanol for 5h; Heating / reflux;70%
piperidine
110-89-4

piperidine

pyrographite
7440-44-0

pyrographite

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol
13551-86-5

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

Pimonidazole
70132-50-2

Pimonidazole

Conditions
ConditionsYield
In methanol; ethanol; water65%
2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol
6338-55-2

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol
13551-86-5

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

C12H22N4O6
1021880-48-7

C12H22N4O6

Conditions
ConditionsYield
With potassium carbonate In methanol for 14h; Heating / reflux;65%
closo-1,2-caboranylethyl-1-(4-amino)butane
1021880-46-5

closo-1,2-caboranylethyl-1-(4-amino)butane

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol
13551-86-5

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

1-[4-(closo-1,2-decaboranylethyl)-butylamino]-3-(2-nitro-imidazol-1-yl)-propan-2-ol
1021880-43-2

1-[4-(closo-1,2-decaboranylethyl)-butylamino]-3-(2-nitro-imidazol-1-yl)-propan-2-ol

Conditions
ConditionsYield
With triethylamine In ethanol for 5h; Heating / reflux;52%
1,2-dicarba-closo-dodecaborane-1-carboxylic acid
18178-04-6

1,2-dicarba-closo-dodecaborane-1-carboxylic acid

trimethylsilylazide
4648-54-8

trimethylsilylazide

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol
13551-86-5

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

1-(chloromethyl)-2-(2-nitroimidazol-1-yl)ethyl N-(1,2-dicarba-closo-dodecaboran(12)-1-yl)carbamate
158565-48-1

1-(chloromethyl)-2-(2-nitroimidazol-1-yl)ethyl N-(1,2-dicarba-closo-dodecaboran(12)-1-yl)carbamate

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide; toluene the carboranecarboxylic acid is boiled under reflux with thionyl chloride and DMF for 4 h, evapd., the residue is dissolved in toluene and treated with azidotrimethylsilane, refluxed for 18 h, cooled, the alcohol isadded, refluxed for 1 h; evapd., the residue is dissolved in chloroform, cooled to 0°C, elem. anal.;38%
α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol
13551-86-5

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

2-nitro-1-(2-oxiranylmethyl)-1H-imidazole
13551-90-1

2-nitro-1-(2-oxiranylmethyl)-1H-imidazole

Conditions
ConditionsYield
With 18-crown-6 ether In acetonitrile
In ethyl acetate at 20℃; for 1h;300 mg
With sodium hydroxide In water; ethyl acetate at 20℃; for 1h;
α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol
13551-86-5

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

1-(4-(aminomethyl)piperidin-1-yl)-3-(2-nitro-1H-imidazol-1-yl)-propan-2-ol

1-(4-(aminomethyl)piperidin-1-yl)-3-(2-nitro-1H-imidazol-1-yl)-propan-2-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: ethyl acetate / 1 h / 20 °C
2.1: ethanol / 0.33 h / 120 °C / Microwave irradiation
2.2: 4 h / 40 °C
View Scheme
α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol
13551-86-5

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

C33H32N6O8S

C33H32N6O8S

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ethyl acetate / 1 h / 20 °C
2.1: ethanol / 0.33 h / 120 °C / Microwave irradiation
2.2: 4 h / 40 °C
3.1: triethylamine / dichloromethane; ethanol / 0.25 h / 80 °C / Microwave irradiation
View Scheme
α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol
13551-86-5

α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

1-(2-hydroxy-3-(N'-1,1,1,3,3,3-hexafluoroisopropylpiperazino))-2-nitroimidazole
1016952-59-2

1-(2-hydroxy-3-(N'-1,1,1,3,3,3-hexafluoroisopropylpiperazino))-2-nitroimidazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water; ethyl acetate / 1 h / 20 °C
2: sodium hydroxide / acetone / Heating / reflux
View Scheme

13551-86-5Relevant articles and documents

Biocatalyzed synthesis of both enantiopure fluoromisonidazole antipodes

Borz?cka, Wioleta,Lavandera, Iván,Gotor, Vicente

, p. 5022 - 5025 (2013)

Fluoromisonidazole (FMISO or F-MISO) is a radiotracer for positron emission tomography when 18F-labeled and is administrated in its racemic form. Herein, a straightforward synthesis of both enantiopure antipodes is proposed through a one-pot two-step microwave protocol to obtain a fluorinated ketone precursor followed by bioreduction using alcohol dehydrogenases from Rhodococcus ruber (ADH-A) or Lactobacillus brevis (LBADH).

Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof

-

Page/Page column 17, (2008/06/13)

The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 13551-86-5