2-chloro-N-(4-methoxyphenyl)-N-methylacetamide

Base Information

Chemical Name:2-chloro-N-(4-methoxyphenyl)-N-methylacetamide
CAS No.:63031-64-1
Molecular Formula:C10H12ClNO2
Molecular Weight:213.664
Hs Code.:
DSSTox Substance ID:DTXSID10405789
Nikkaji Number:J1.384.970F
Wikidata:Q82210497
ChEMBL ID:CHEMBL2164316

Synonyms:2-chloro-N-(4-methoxyphenyl)-N-methylacetamide;63031-64-1;SCHEMBL9732732;CHEMBL2164316;DTXSID10405789;QJCJMBSFRSSXCB-UHFFFAOYSA-N;AKOS011249075;N-Methyl-p-methoxy-alpha-chloroacetoanilide;Z905093740

Suppliers and Price of 2-chloro-N-(4-methoxyphenyl)-N-methylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-chloro-N-(4-methoxyphenyl)-N-methylacetamide

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:213.0556563
Heavy Atom Count:14
Complexity:191

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C1=CC=C(C=C1)OC)C(=O)CCl

Technology Process of 2-chloro-N-(4-methoxyphenyl)-N-methylacetamide

There total 4 articles about 2-chloro-N-(4-methoxyphenyl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 79-04-9
chloroacetyl chloride

: 5961-59-1
N-methyl-N-(4-methoxyphenyl)amine

: 63031-64-1
2-chloro-N-(4-methoxy-phenyl)-N-methylacetamide

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; water; Ambient temperature;
DOI:10.1248/cpb.29.128

Reference yield: 84.0%

: 22303-36-2
N-(4-methoxyphenyl)-2-chloroacetamide

: 74-88-4
methyl iodide

: 63031-64-1
2-chloro-N-(4-methoxy-phenyl)-N-methylacetamide

Guidance literature:: N-(4-methoxyphenyl)-2-chloroacetamide; With potassium tert-butylate; In tetrahydrofuran; at -78 ℃; for 0.333333h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at -78 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c6ob01712f

Reference yield:

: 104-94-9
4-methoxy-aniline

: 63031-64-1
2-chloro-N-(4-methoxy-phenyl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 0 °C

1.2: 17 h / 0 - 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 °C / Inert atmosphere

With potassium tert-butylate; sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1039/c6ob01712f