Pyridine, 3-[(4-methylphenyl)methyl]-

Base Information

• Chemical Name: Pyridine, 3-[(4-methylphenyl)methyl]-
• CAS No.: 63065-68-9
• Molecular Formula: C13H13N
• Molecular Weight: 183.253
• Mol file: 63065-68-9.mol

Synonyms:

Chemical Property of Pyridine, 3-[(4-methylphenyl)methyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyridine, 3-[(4-methylphenyl)methyl]-

There total 10 articles about Pyridine, 3-[(4-methylphenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-methylphenylboronic acid (5720-05-8) + 2,4,6‐triphenyl‐1-(pyridin-3-ylmethyl)pyridin‐1‐ium tetrafluoroborate → 3‐(4‐methylbenzyl)pyridine (63065-68-9)

Guidance literature:

With potassium phosphate; 2C₂H₃O₂^(1-)*C₁₂H₈N₂*(x)H₂O*Ni⁽²⁺⁾; In 1,4-dioxane; ethanol; at 60 ℃; for 5h; Reagent/catalyst; Concentration; Solvent; Catalytic behavior; Schlenk technique; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01062

Reference yield: 91.0%

(3-pyridyl)AlEt2(OEt2) + 4-Methylbenzyl chloride (104-82-5) → 3‐(4‐methylbenzyl)pyridine (63065-68-9)

Guidance literature:

With palladium diacetate; tris-(o-tolyl)phosphine; In toluene; at 60 ℃; for 10h; Inert atmosphere;

DOI:10.1021/jo4024123

Reference yield: 76.0%

3-Aminomethylpyridine (3731-52-0) + 4-methylphenylboronic acid (5720-05-8) → 3‐(4‐methylbenzyl)pyridine (63065-68-9)

Guidance literature:

With potassium phosphate; 2C₂H₃O₂^(1-)*C₁₂H₈N₂*(x)H₂O*Ni⁽²⁺⁾; 2,4,6-triphenylpyrylium tetrafluoroborate; In 1,4-dioxane; ethanol; at 60 ℃; for 24h; Schlenk technique; Molecular sieve; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01062

upstream raw materials:

4-methyl-benzaldehyde

1,4-bis(trimethylsilyl)-1-aza-2,5-cyclohexadiene

pyridine

3-Chloropyridine