1-BOC-3-(4'-FLUOROPHENYL)-PIPERIDIN-4-ONE

Base Information

Chemical Name:1-BOC-3-(4'-FLUOROPHENYL)-PIPERIDIN-4-ONE
CAS No.:632352-74-0
Molecular Formula:C16H20FNO3
Molecular Weight:293.338
Hs Code.:
Mol file:632352-74-0.mol

Synonyms:1-tert-butoxycarbonyl-3-(4-fluoro-phenyl)-4-piperidone;tert-butyl 3-(4-fluorophenyl)-4-oxopiperidine-1-carboxylate;1-tert-butoxycarbonyl-3-(4-fluorophenyl)-4-piperidone;

Suppliers and Price of 1-BOC-3-(4'-FLUOROPHENYL)-PIPERIDIN-4-ONE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 1-BOC-3-(4'-FLUOROPHENYL)-PIPERIDIN-4-ONE

Chemical Property:

PSA：46.61000
LogP:3.05710

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-BOC-3-(4'-FLUOROPHENYL)-PIPERIDIN-4-ONE

There total 3 articles about 1-BOC-3-(4'-FLUOROPHENYL)-PIPERIDIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 460-00-4
1-Bromo-4-fluorobenzene

: 632352-74-0
tert-butyl 3-(4-fluorophenyl)-4-oxopiperidine-1-carboxylate

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 20 - 60 ℃; for 7.08333h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1263870-41-2
ethyl 3-((3-ethoxy-3-oxopropyl)amino)-2-(4-fluorophenyl)propanoate

: 632352-74-0
tert-butyl 3-(4-fluorophenyl)-4-oxopiperidine-1-carboxylate

Guidance literature:: ethyl 3-((3-ethoxy-3-oxopropyl)amino)-2-(4-fluorophenyl)propanoate; With sodium hydride; In tetrahydrofuran; for 0.5h; Cooling with ice; Inert atmosphere; Reflux;

With hydrogenchloride; acetic acid; In water; for 16h; Reflux;

di-tert-butyl dicarbonate; With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

: 587-88-2
ethyl 2-(4-fluorophenyl)acetate

: 632352-74-0
tert-butyl 3-(4-fluorophenyl)-4-oxopiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 16 h / 140 °C / Inert atmosphere

1.2: 2 h / 80 °C

1.3: 1.5 h / 20 °C / Cooling with ice; Reflux

2.1: sodium hydride / tetrahydrofuran / 0.5 h / Cooling with ice; Inert atmosphere; Reflux

2.2: 16 h / Reflux

2.3: 0.5 h / 20 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;