1263870-41-2

Upstream product

• 140-88-5 ethyl acrylate 
• 459-22-3 4-fluorophenylacetonitrile 
• 4244-84-2 ethyl β-alaninate hydrochloride 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 587-88-2 ethyl 2-(4-fluorophenyl)acetate 
• 7054-58-2 ethyl 2-cyano-2-(4-fluorophenyl)acetate 

Downstream Products

• 1263870-42-3 ethyl 3-((3-ethoxy-3-oxopropyl)(4-methoxybenzyl)amino)-2-(4-fluorophenyl)propanoate 
• 1310535-78-4 ethyl 3-((3-ethoxy-3-oxopropyl)(methyl)amino)-2-(4-fluorophenyl)propanoate 
• 632352-74-0 tert-butyl 3-(4-fluorophenyl)-4-oxopiperidine-1-carboxylate 
• 1356008-84-8 (+/-)-19-(4-fluorophenyl)-17-methyl-7-(3-methyl-1H-1,2,4-triazol-1-yl)-11,12,13,14,16,17,18,19-octahydro-10H-15,2-(azeno)-8,4-(metheno)pyrido[3,4-h][1,6,10,12]oxatriazacycloheptadecine trifluoroacetate 
• 1356010-68-8 4-(4-(allyl(methyl)amino)-8-(4-fluorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-ylamino)-2-(allyloxy)benzonitrile trifluoroacetate 
• 1356010-63-3 N-(4-(5-amino-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)butyl)-2-chloro-8-(4-fluorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine 
• 1356010-09-7 N-allyl-2-chloro-8-(4-fluorophenyl)-N,6-dimethyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine 
• 1356010-06-4 4-amino-2-(4-(2-chloro-8-(4-fluorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ylamino)butoxy)benzonitrile 
• 1263870-64-9 2-chloro-N,6-dimethyl-N-ethyl-8-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine 
• 1263870-63-8 2-chloro-N-ethyl-8-(4-fluorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine 
• 1263870-62-7 2-chloro-8-(4-fluorophenyl)-N,6-dimethyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine 
• 1263870-59-2 2,4-dichloro-8-(4-fluorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 
• 1263870-61-6 8-(4-fluorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione 
• 1263870-60-5 ethyl 5-(4-fluorophenyl)-1-methyl-4-oxopiperidine-3-carboxylate 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUND

The present invention relates to N-((3S,4R)-1-((8-chloroquinoxalin-6-yl)carbonyl)-3-(4-fluorophenyl)piperidin-4-yl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxamide, which is a compound that can be useful for the treatment or prevention of SPT-related diseases including congenital diseases associated with the storage of sphingolipids, such as cancer and Niemann-Pick disease, or a salt thereof.

HETEROCYCLIC COMPOUND

The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).

COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION

Compounds of the formula (I) are provided, including pharmaceutically acceptable salts thereof: which modulate β-amyloid peptide (β-AP) production, and are useful in the treatment of Alzheimer's Disease and other conditions affected by -amyloid peptide (β-AP) production.

COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION

The present disclosure provides a series of compounds of the formula (I), which modulate β-amyloid peptide (β-ΑΡ) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-ΑΡ) production.

COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION

The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.