2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-6-methoxyaniline

Base Information

Chemical Name:2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-6-methoxyaniline
CAS No.:63478-14-8
Molecular Formula:C12H16N2O2
Molecular Weight:220.271
Hs Code.:
DSSTox Substance ID:DTXSID30495006
Wikidata:Q82342829

Synonyms:63478-14-8;2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-6-methoxyaniline;DTXSID30495006;2-(4,4-Dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-6-methoxyaniline

Suppliers and Price of 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-6-methoxyaniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-6-methoxyaniline

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:220.121177757
Heavy Atom Count:16
Complexity:289

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(COC(=N1)C2=C(C(=CC=C2)OC)N)C

Technology Process of 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-6-methoxyaniline

There total 4 articles about 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-6-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.5%

: 34954-65-9
3-methoxyisatoic anhydride

: 124-68-5
2-Amino-2-methyl-1-propanol

: 63478-14-8
2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-6-methoxyaniline

Guidance literature:: With zinc(II) chloride; In chlorobenzene; at 140 ℃; Inert atmosphere;
DOI:10.1021/jm201179h

Reference yield:

: 57598-32-0
4,5-dihydro-2-(2',3'-dimethoxyphenyl)-4,4-dimethyloxazole

: 63478-14-8
2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-6-methoxyaniline

Guidance literature:: With lithium amide; In tetrahydrofuran;
DOI:10.1021/jo00435a036

Reference yield:

: 3177-80-8
2-amino-3-methoxybenzoic acid

: 63478-14-8
2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-6-methoxyaniline

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; water / 2 h / 0 - 20 °C

2: zinc(II) chloride / chlorobenzene / 24 h / 130 °C / Inert atmosphere; Reflux

With zinc(II) chloride; In tetrahydrofuran; water; chlorobenzene;
DOI:10.1039/c5md00062a