Phthalazine, 1-(phenylmethyl)-

Base Information

• Chemical Name: Phthalazine, 1-(phenylmethyl)-
• CAS No.: 63536-21-0
• Molecular Formula: C15H12N2
• Molecular Weight: 220.274
• Mol file: 63536-21-0.mol

Synonyms:

Chemical Property of Phthalazine, 1-(phenylmethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phthalazine, 1-(phenylmethyl)-

There total 7 articles about Phthalazine, 1-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

diethyl (2‐(2‐(phenylethynyl)benzylidene)hydrazineyl)phosphonate → 1‐benzylphthalazine (63536-21-0)

Guidance literature:

With methanol; tris(2,2'‐bipyridine)ruthenium(II) hexafluorophosphate; sodium t-butanolate; at 20 ℃; for 16h; Reagent/catalyst; Sealed tube; Irradiation;

DOI:10.1002/adsc.202000018

Reference yield: 45.0%

P,P‐diphenyl‐N'‐(2‐(phenylethynyl)benzylidene)phosphinic hydrazide → 1‐benzylphthalazine (63536-21-0) + 1-benzhydrylphthalazine

Guidance literature:

With tris(bipyridine)ruthenium(II) dichloride hexahydrate; sodium hydroxide; In propan-1-ol; at 20 ℃; Molecular sieve; Irradiation;

DOI:10.1021/acs.joc.0c02540

Reference yield:

o-(phenylethynyl)benzaldehyde (59046-72-9) → 2-(2-(isoquinolin-3-yl)phenyl)-1-phenylethan-1-one + C21H15FN2O2S + 3-phenylisoquinoline (37993-76-3) + C21H15ClN2O2S + C19H14N2O2S2 + C24H22N2O2S + 1‐benzylphthalazine (63536-21-0) + 1-benzhydrylphthalazine

Guidance literature:

With (AuCl)2MeOBIPHEP; silver(I) triflimide; In 1,2-dichloro-ethane; at -30 ℃; Temperature; Reagent/catalyst; Solvent; Overall yield = 88 percent; Overall yield = 139 mg; enantioselective reaction; Catalytic behavior; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03963

upstream raw materials:

1-benzyl-4-chlorophthalazine

hydrogen iodide

o-(phenylethynyl)benzaldehyde

Downstream raw materials:

1-benzoylphthalazine