Benzyl 4-(2-chloro-2-oxoethyl)piperidine-1-carboxylate

Base Information

Chemical Name:Benzyl 4-(2-chloro-2-oxoethyl)piperidine-1-carboxylate
CAS No.:63845-29-4
Molecular Formula:C15H18ClNO3
Molecular Weight:295.766
Hs Code.:
DSSTox Substance ID:DTXSID001186221

Synonyms:63845-29-4;benzyl 4-(2-chloro-2-oxoethyl)piperidine-1-carboxylate;1-PIPERIDINECARBOXYLIC ACID, 4-(2-CHLORO-2-OXOETHYL)-, PHENYLMETHYLESTER;Benzyl 4-(2-chloro-2-oxo-ethyl)piperidine-1-carboxylate;2-(1-Cbz-4-piperidyl)acetyl Chloride;MFCD22571564;starbld0049597;SCHEMBL9372786;PSZQPESLSOKKES-UHFFFAOYSA-N;DTXSID001186221;SB73783;BS-43725;SY274694;1-Cbz-4-(2-chloro-2-oxo-ethyl)piperidine;DB-360155;1-benzyloxycarbonyl-4-piperidyl-acetyl chloride;2-(N-Cbz-piperidin-4-yl)acetic acid chloride;D84876;Phenylmethyl 4-(2-chloro-2-oxoethyl)-1-piperidinecarboxylate;(phenylmethyl) 4-(2- chloro-2-oxoethyl)-1-piperidinecarboxylate

Suppliers and Price of Benzyl 4-(2-chloro-2-oxoethyl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Benzyl 4-(2-chloro-2-oxoethyl)piperidine-1-carboxylate

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:295.0975211
Heavy Atom Count:20
Complexity:334

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1CC(=O)Cl)C(=O)OCC2=CC=CC=C2

Technology Process of Benzyl 4-(2-chloro-2-oxoethyl)piperidine-1-carboxylate

There total 2 articles about Benzyl 4-(2-chloro-2-oxoethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 63845-29-4
benzyl 4-(2-chloro-2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 16 h / 20 °C / Cooling with ice

2: thionyl chloride / dichloromethane / 4 h / 80 °C / Inert atmosphere

With thionyl chloride; sodium hydroxide; In dichloromethane; water;

Reference yield:

: 73415-84-6
2-(piperidin-4-yl)acetic acid hydrochloride

: 63845-29-4
benzyl 4-(2-chloro-2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 16 h / 20 °C / Cooling with ice

2: thionyl chloride / dichloromethane / 4 h / 80 °C / Inert atmosphere

With thionyl chloride; sodium hydroxide; In dichloromethane; water;

Reference yield: 66.0%

: 63845-29-4
benzyl 4-(2-chloro-2-oxoethyl)piperidine-1-carboxylate

: 1215-59-4
5-benzyloxy-1H-indole

: 1622247-25-9
benzyl 4-[2-(5-(benzyloxy)-1H-indol-3-yl)-2-oxoethyl]piperidine-1-carboxylate

Guidance literature:: 5-benzyloxy-1H-indole; With iodine; magnesium; methyl iodide; In diethyl ether; at 60 ℃; for 1h;

benzyl 4-(2-chloro-2-oxoethyl)piperidine-1-carboxylate; In diethyl ether; dichloromethane; at 0 - 20 ℃; for 1.5h; Reagent/catalyst; Temperature;