benzyl 4-[2-(5-(benzyloxy)-1H-indol-3-yl)-2-oxoethyl]piperidine-1-carboxylate

Base Information

Chemical Name:benzyl 4-[2-(5-(benzyloxy)-1H-indol-3-yl)-2-oxoethyl]piperidine-1-carboxylate
CAS No.:1622247-25-9
Molecular Formula:C₃₀H₃₀N₂O₄
Molecular Weight:482.579
Hs Code.:

Synonyms:benzyl 4-[2-(5-(benzyloxy)-1H-indol-3-yl)-2-oxoethyl]piperidine-1-carboxylate

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Chemical Property of benzyl 4-[2-(5-(benzyloxy)-1H-indol-3-yl)-2-oxoethyl]piperidine-1-carboxylate

Chemical Property:

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Technology Process of benzyl 4-[2-(5-(benzyloxy)-1H-indol-3-yl)-2-oxoethyl]piperidine-1-carboxylate

There total 6 articles about benzyl 4-[2-(5-(benzyloxy)-1H-indol-3-yl)-2-oxoethyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 63845-29-4
benzyl 4-(2-chloro-2-oxoethyl)piperidine-1-carboxylate

: 1215-59-4
5-benzyloxy-1H-indole

: 1622247-25-9
benzyl 4-[2-(5-(benzyloxy)-1H-indol-3-yl)-2-oxoethyl]piperidine-1-carboxylate

Guidance literature:: 5-benzyloxy-1H-indole; With iodine; magnesium; methyl iodide; In diethyl ether; at 60 ℃; for 1h;

benzyl 4-(2-chloro-2-oxoethyl)piperidine-1-carboxylate; In diethyl ether; dichloromethane; at 0 - 20 ℃; for 1.5h; Reagent/catalyst; Temperature;

Reference yield:

: 73415-84-6
2-(piperidin-4-yl)acetic acid hydrochloride

: 1622247-25-9
benzyl 4-[2-(5-(benzyloxy)-1H-indol-3-yl)-2-oxoethyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / 16 h / 20 °C / Cooling with ice

2.1: thionyl chloride / dichloromethane / 4 h / 80 °C / Inert atmosphere

3.1: magnesium; iodine; methyl iodide / diethyl ether / 1 h / 60 °C

3.2: 1.5 h / 0 - 20 °C

With thionyl chloride; iodine; magnesium; sodium hydroxide; methyl iodide; In diethyl ether; dichloromethane; water;

Reference yield:

: 63845-28-3
2-(1-((benzyloxy)carbonyl)piperidin-4-yl)acetic acid

: 1622247-25-9
benzyl 4-[2-(5-(benzyloxy)-1H-indol-3-yl)-2-oxoethyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / dichloromethane / 4 h / 80 °C / Inert atmosphere

2.1: magnesium; iodine; methyl iodide / diethyl ether / 1 h / 60 °C

2.2: 1.5 h / 0 - 20 °C

With thionyl chloride; iodine; magnesium; methyl iodide; In diethyl ether; dichloromethane;