4-Methoxyphenyl acetate

Base Information

• Chemical Name: 4-Methoxyphenyl acetate
• CAS No.: 1200-06-2
• Molecular Formula: C9H10 O3
• Molecular Weight: 166.177
• Hs Code.: 2915390090
• European Community (EC) Number: 839-657-0
• NSC Number: 43148
• UNII: 5R7WLL62AN
• DSSTox Substance ID: DTXSID50152649
• Nikkaji Number: J100.255D
• Wikidata: Q83019347
• ChEMBL ID: CHEMBL40604
• Mol file: 1200-06-2.mol

Synonyms:4-Methoxyphenyl acetate;1200-06-2;p-Acetoxyanisole;p-Methoxyphenyl acetate;(4-methoxyphenyl) acetate;Acetic acid p-methoxyphenyl ester;Phenol, p-methoxy-, acetate;Phenol, 4-methoxy-, acetate;Acetic acid 4-methoxy-phenyl ester;4-methoxy phenyl acetic acid;NSC 43148;NSC-43148;Phenol, p-methoxy-, acetate (8CI);Benzenemethanol, ar-methoxy-, 1-acetate;AI3-22704;4-Acetoxyanisole;4-Methoxyphenol acetate;4-Methoxyphenol, acetate;5R7WLL62AN;CHEMBL40604;SCHEMBL155983;Phenol, 4-methoxy-, 1-acetate;DTXSID50152649;AMY39827;BAA20006;NSC43148;MFCD00048211;Benzenemethanol,ar-methoxy-,1-acetate;AKOS002953963;BS-14538;CS-0155015;FT-0693816;EN300-169864;A804409;Z30195429

Chemical Property of 4-Methoxyphenyl acetate

Chemical Property:

• Boiling Point: 246.1°Cat760mmHg
• Flash Point: 96.4°C
• PSA: 35.53000
• Density: 1.099g/cm³
• LogP: 1.62050
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 166.062994177
• Heavy Atom Count: 12
• Complexity: 148

Purity/Quality:

97% ^*data from raw suppliers

4-Methoxyphenylacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OC1=CC=C(C=C1)OC

Technology Process of 4-Methoxyphenyl acetate

There total 75 articles about 4-Methoxyphenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxy-phenol (150-76-5) + acetyl chloride (75-36-5) → 4-methoxyphenyl acetate (1200-06-2)

Guidance literature:

4-methoxy-phenol; acetyl chloride; With triethylamine; In chloroform; at 20 ℃; for 24h;

With sodium hydrogencarbonate; In water;

Reference yield: 98.0%

4-methoxy-phenol (150-76-5) + 2-acetyl-4,5-dichloropyridazin-3(2H)-one (155164-63-9) → 4-methoxyphenyl acetate (1200-06-2)

Guidance literature:

4-methoxy-phenol; With aluminum (III) chloride; In tetrahydrofuran; for 0.0166667h;

2-acetyl-4,5-dichloropyridazin-3(2H)-one; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

DOI:10.1055/s-0034-1378335

Reference yield: 42.0%

acetic acid (64-19-7,77671-22-8) + methoxybenzene (100-66-3) → 2-methoxyphenyl acetate (613-70-7) + 4-methoxyphenyl acetate (1200-06-2)

Guidance literature:

With sodium nitrate; acetic anhydride; trifluoroacetic acid; at 0 ℃; for 14h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02183

upstream raw materials:

1-methoxy-4-(1-methylethyl)benzene

acetic anhydride

toluene-4-sulfonic acid

4-methoxy-phenol

Downstream raw materials:

N-acetyl-1-dodecylamine

propionic acid

4-methoxy-phenol

acetate