(R)-(+)-Bornylamine

Base Information

• Chemical Name: (R)-(+)-Bornylamine
• CAS No.: 32511-34-5
• Molecular Formula: C10H19 N
• Molecular Weight: 153.268
• Hs Code.: 29213000
• European Community (EC) Number: 251-076-9
• DSSTox Substance ID: DTXSID30947530
• Nikkaji Number: J1.251.144B
• ChEMBL ID: CHEMBL3735331
• Mol file: 32511-34-5.mol

Synonyms:(R)-(+)-Bornylamine;32511-34-5;(1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine;(+)-bornylamine;SCHEMBL542034;Bicyclo(2.2.1)heptan-2-amine, 1,7,7-trimethyl-, (1R-endo)-;CHEMBL3735331;(R)-(+)-Bornylamine, 97%;DTXSID30947530;MDFWXZBEVCOVIO-WEDXCCLWSA-N;AKOS015915781;AS-81150;(R)-(+)-Bornylamine, purum, >=97.0% (NT)

Chemical Property of (R)-(+)-Bornylamine

Chemical Property:

• Vapor Pressure: 0.591mmHg at 25°C
• Melting Point: 160-163 °C(lit.)
• Refractive Index: 1.4600 (estimate)
• Boiling Point: 189 ºC
• PKA: 11.01±0.60(Predicted)
• Flash Point: 48 ºC
• PSA: 26.02000
• Density: 0.923
• LogP: 2.86020
• Storage Temp.: 2-8°C
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 153.151749610
• Heavy Atom Count: 11
• Complexity: 185

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-(+)-Bornylamine 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(C2CCC1(C(C2)N)C)C
• Isomeric SMILES: C[C@@]12CC[C@@H](C1(C)C)C[C@@H]2N

Technology Process of (R)-(+)-Bornylamine

There total 29 articles about (R)-(+)-Bornylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

endo-(aS)-N-(α-phenylethyl)bornylamine → (R)-Bornylamine (32511-34-5)

Guidance literature:

With 10% palladium hydroxide on charcoal; ammonium formate; In ethanol; for 2.5h; Schlenk technique; Inert atmosphere; Reflux;

DOI:10.1039/d1nj04526a

Reference yield: 69.0%

ethanol (64-17-5) + (1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one (464-49-3,68546-28-1) → ((1R,4R)-1,7,7-Trimethyl-bicyclo[2.2.1]hept-2-yl)-[(1R,4R)-1,7,7-trimethyl-bicyclo[2.2.1]hept-(2E)-ylidene]-amine + exo-bornylamine (32511-35-6) + (R)-Bornylamine (32511-34-5) + exo N-ethylbornylamine (76184-19-5,76231-56-6,93532-13-9,94062-71-2,102045-47-6)

Guidance literature:

With ammonium chloride; ammonia; hydrogen; palladium on activated charcoal; at 200 ℃; for 5h; under 8 Torr; Further byproducts given;

DOI:10.1016/j.tet.2004.12.062

Reference yield: 16.0%

ethanol (64-17-5) + (1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one (464-49-3,68546-28-1) → Bis-((1R,4R)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl)-amine + exo-bornylamine (32511-35-6) + (R)-Bornylamine (32511-34-5) + exo N-ethylbornylamine (76184-19-5,76231-56-6,93532-13-9,94062-71-2,102045-47-6)

Guidance literature:

With ammonium chloride; ammonia; hydrogen; palladium; at 200 ℃; for 5h; under 60004.8 Torr; Further byproducts given;

DOI:10.1016/j.tet.2004.12.062

upstream raw materials:

(R,R)-camphor oxime

Camphor

ammonium formate

(-)-2exo-bromo-2endo-nitro-bornane

Downstream raw materials:

4R-α-terpineol

(+)-camphene

2-vinylbenzaldehyde

(-)-bornylene

Refernces

• 1、 -. "CYANO-PYRIMIDINE INHIBITORS OF EGFR/HER2". Page/Page column 58-59. . Retrieved 2021/07/17.
• 2、 Pacu?a, Agata J.,Kaczor, Katarzyna B.,Antosiewicz, J?drzej,D?ugosz, Angelika,Janecka, Anna,Janecki, Tomasz,Wojtczak, Andrzej,?cianowski, Jacek,Santi, Claudio,Bagnoli, Luana,Dembinski, Roman. "New chiral ebselen analogues with antioxidant and cytotoxic potential". . . Retrieved 2017/04/03.